@misc{Parry_R-2021_39595,
title = {No evidence of SARS-CoV-2 reverse transcription and integration as the origin of chimeric transcripts in patient tissues},
author = {Parry, R. and Gifford, R. and Lytras, S. and Ray, S. and Coin, L.},
month = {aug},
year = {2021},
abstract = {There is interest in understanding the mechanisms that underlie reports that patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remain PCR positive many weeks after initial infection. The recent paper by Zhang et al. (1) suggests a potential explanation of this phenomenon by claiming that SARS-CoV-2 RNA can integrate into the genome of infected human cells. The authors also reanalyze RNA sequencing (RNA-seq) data and report that SARS-CoV-2−host chimeric reads are present in cells and patient tissues. Given the potential implications of this research on the long-term impacts of COVID-19, we feel that it’s necessary to scrutinize the evidence presented.},
volume = {118},
issue = {33},
journal = {Proceedings of the National Academy of Sciences of the United States of America},
publisher = {National Academy of Sciences},
url = {https://doi.org/10.1073/pnas.2109066118},
}
