@article{Sattar_N-2021_40015,
title = {Obesity as a risk factor for severe COVID-19: summary of the best evidence and implications for health care},
author = {Sattar, N. and Valabhji, J.},
month = {aug},
year = {2021},
abstract = {Purpose of Review: To collate the best evidence from several strands—epidemiological, genetic, comparison with historical data and mechanistic information—and ask whether obesity is an important causal and potentially modifiable risk factor for severe COVID-19 outcomes. Recent Findings: Several hundred studies provide powerful evidence that body mass index (BMI) is a strong linear risk factor for severe COVID-19 outcomes, with recent studies suggesting ~5-10% higher risk for COVID-19 hospitalisation per every kg/m2 higher BMI. Genetic data concur with hazard ratios increasing by 14% per every kg/m2 higher BMI. BMI to COVID-19 links differ markedly from prior BMI-infection associations and are further supported as likely causal by multiple biologically plausible pathways. Summary: Excess adiposity appears to be an important, modifiable risk factor for adverse COVID-19 outcomes across all ethnicities. The pandemic is also worsening obesity levels. It is imperative that medical systems worldwide meet this challenge by upscaling investments in obesity prevention and treatments.},
pages = {282-289},
volume = {10},
journal = {Health Services and Programs },
publisher = {Springer Nature},
url = {https://doi.org/10.1007/s13679-021-00448-8},
}
