@article{Anderson_J-2021_40083,
title = {Remote history of VTE is associated with severe COVID-19 in middle and older age: UK Biobank cohort study},
author = {Anderson, J. and Ho, F. and Niedzwiedz, C. and Katikireddi, S. and Celis-Morales, C. and Iliodromiti, S. and Welsh, P. and Pellicori, P. and Demou, E. and Hastie, C. and Lyall, D. and Gray, S. and Forbes, J. and Gill, J. and Mackay, D. and Berry, C. and Cleland, J. and Sattar, N. and Pell, J.},
month = {jul},
year = {2021},
abstract = {Background: Venous thromboembolism (VTE) is a common, life-threatening complication of COVID-19 infection. COVID-19 risk-prediction models include a history of venous thromboembolism. However, it is unclear whether remote history (&gt;9 years previously) of VTE also confers increased risk of COVID-19. Objectives: To investigate possible association between VTE and COVID-19 severity, independent of other risk factors. Methods: Cohort study of UK Biobank participants recruited between 2006-2010. Baseline data, including history of VTE, were linked to COVID-19 test results, COVID-19 related hospital admissions and COVID-19 deaths. The risk of COVID-19 hospitalisation or death was compared for participants with a remote history VTE versus without. Poisson regression models were run univariately then adjusted stepwise for socio-demographic, lifestyle and comorbid covariates. Results: After adjustment for socio-demographic and lifestyle confounders and comorbid conditions, remote history of VTE was associated with non-fatal community (RR 1.61, 95% CI 1.02-2.54, p=0.039), non-fatal hospitalised (RR 1.52, 95% CI 1.06-2.17, p=0.024) and severe (hospitalised or fatal) (RR 1.40, 95% CI 1.04-1.89, p=0.025) COVID-19. Associations with remote history of VTE were stronger among men (severe COVID-19: RR 1.68, 95% CI 1.14-2.42, p=0.009) than for women (severe COVID-19: RR 1.07, 95% CI 0.66-1.74, p=0.786). Conclusion: Our findings support inclusion of remote history of VTE in COVID-19 risk-prediction scores, and consideration of sex-specific risk scores.},
pages = {1-6},
issue = {00},
journal = {Journal of Thrombosis and Haemostasis},
publisher = {Wiley},
url = {http://dx.doi.org/10.1111/jth.15452},
}
