@article{Abdukahil_S-2021_40090,
title = {COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study},
author = {Abdukahil, S. and Abe, R. and Abel, L. and Absil, L. and Acker, A. and Adachi, S. and Adam, E. and Adrião, D. and Ainscough, K. and Ait Hssain, A. and Ait Tamlihat, Y. and Akimoto, T. and Al-Dabbous, T. and Al-Fares, A. and Al Qasim, E. and Alalqam, R. and Alex, B. and Alexandre, K. and Alfoudri, H. and Alidjnou, K. and Aliudin, J. and Allavena, C. and Allou, N. and Alves, J. and Alves, R. and Amaral, M. and Ammerlaan, H. and Ampaw, P. and Andini, R. and Andrejak, C. and Angheben, A. and Angoulvant, F. and Ansart, S. and Antonelli, M. and De Brito, C. and Arabi, Y. and Aragao, I. and Arcadipane, A. and Arenz, L. and Arlet, J. and Arnold-Day, C. and Arora, L. and Artaud-Macari, E. and Asensio, A. and Assie, J. and Atique, A. and Auchabie, J. and Aumaitre, H. and Azemar, L. and Azoulay, C. and Bach, B. and Bachelet, D. and Baillie, J. and Bak, E. and Bakakos, A. and Banisadr, F. and Barbalho, R. and Barclay, W. and Barnikel, M. and Barrelet, A. and Barrigoto, C. and Basmaci, R. and Rincon, D. and Bedossa, A. and Behillil, S. and Beljantsev, A. and Bellemare, D. and Beltrame, A. and Beluze, M. and Benech, N. and Benkerrou, D. and Bennett, S. and Bento, L. and Berdal, J. and Bergeaud, D. and Bertolino, L. and Bessis, S. and Bevilcaqua, S. and Bhavsar, K. and Humaid, F. and Bissuel, F. and Biston, P. and Bitker, L. and Blanco-Schweizer, P. and Blot, M. and Boccia, F. and Bogaert, D. and Bompart, F. and Booth, G. and Borges, D. and Borie, R. and Bos, J. and Bosse, H. and Botelho-Nevers, E. and Bouadma, L. and Bouchaud, O. and Bouchez, S. and Bouhmani, D. and Bouhour, D. and Bouiller, K. and Bouillet, L. and Bouisse, C. and Boureau, A. and Bouscambert, M. and Bouziotis, J. and Boxma, B. and Boyer-Besseyre, M. and Boylan, M. and Braga, C. and Brandenburger, T. and Brazzi, L. and Breen, D. and Breen, P. and Brickell, K. and Brozzi, N. and Buchtele, N. and Buesaquillo, C. and Bugaeva, P. and Buisson, M. and Burhan, E. and Bustos, I. and Butnaru, D. and Cárcel, S. and Cabie, A. and Cabral, S. and Caceres, E. and Callahan, M. and Calligy, K. and Calvache, J. and Camões, J. and Campana, V. and Campbell, P. and Canepa, C. and Cantero, M. and Caraux-Paz, P. and Cardoso, F. and Cardoso, F. and Cardoso, S. and Carelli, S. and Carlier, N. and Carney, G. and Carpenter, C. and Carret, M. and Carrier, F. and Carson, G. and Casanova, M. and Cascão, M. and Casimiro, J. and Cassandra, B. and Castañeda, S. and Castanheira, N. and Castor-Alexandre, G. and Castrillón, H. and Castro, I. and Catarino, A. and Catherine, F. and Cavalin, R. and Cavalli, G. and Cavayas, A. and Ceccato, A. and Cervantes-Gonzalez, M. and Chair, A. and Chakveatze, C. and Chan, A. and Chand, M. and Chas, J. and Chassin, C. and Chen, A. and Chen, Y. and Cheng, M. and Cheret, A. and Chiarabini, T. and Chica, J. and Chirouze, C. and Chiumello, D. and Cho, H. and Cho, S. and Cholley, B. and Cidade, J. and Herreros, J. and Citarella, B. and Ciullo, A. and Clarke, J. and Clohisey, S. and Codan, C. and Cody, C. and Coelho, A. and Colin, G. and Collins, M. and Colombo, S. and Combs, P. and Connelly, J. and Connor, M. and Conrad, A. and Contreras, S. and Cooke, G. and Copland, M. and Cordel, H. and Corley, A. and Cormican, S. and Cornelis, S. and Corpuz, A. and Corvaisier, G. and Couffignal, C. and Couffin-Cadiergues, S. and Courtois, R. and D'Orleans, C. and Croonen, S. and Crowl, G. and Crump, J. and Cruz, C. and Csete, M. and Cucino, A. and Cullen, C. and Cummings, M. and Curley, G. and Curlier, E. and Custodio, P. and D'Aragon, F. and da Silva Filipe, A. and da Silveira, C. and D'Ortenzio, E. and Dabaliz, A. and Dagens, A. and Dalton, H. and Dalton, J. and Daneman, N. and Dankwa, E. and Dantas, J. and De Castro, N. and De Mendoza, D. and De Oliveira França, R. and De Rosa, R. and de Silva, T. and De Vries, P. and Dean, D. and Debray, M. and Dechert, W. and Deconninck, L. and Decours, R. and Delacroix, I. and Delavigne, K. and Deligiannis, I. and Dell’amore, A. and Delobel, P. and Demonchy, E. and Denis, E. and Deplanque, D. and Depuydt, P. and Desai, M. and Descamps, D. and Desvallée, M. and Dewayanti, S. and Diallo, A. and Diamantis, S. and Dias, A. and Diaz, J. and Diaz, R. and Didier, K. and Diehl, J. and Dieperink, W. and Dimet, J. and Dinot, V. and Diouf, A. and Dishon, Y. and Djossou, F. and Docherty, A. and Dong, A. and Donnelly, C. and Donnelly, M. and Donohue, C. and Dorival, C. and Douglas, J. and Douma, R. and Dournon, N. and Downer, T. and Downing, M. and Drake, T. and Dubee, V. and Dubos, F. and Ducancelle, A. and Dudman, S. and Dunning, J. and Mangoni, E. and Duranti, S. and Durham, L. and Dussol, B. and Duval, X. and Dyrhol-Riise, A. and Eira, C. and Vidal, J. and Sanharawi, M. and Elapavaluru, S. and Elharrar, B. and Elkheir, N. and Ellerbroek, J. and Ellis, R. and Eloy, P. and Elshazly, T. and Enderle, I. and Engelmann, I. and Enouf, V. and Epaulard, O. and Esperatti, M. and Esperou, H. and Esposito-Farese, M. and Estevão, J. and Etienne, 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Yokoyama, T. and Yonis, H. and Young, P. and Yuliarto, S. and Zabbe, M. and Zacharowski, K. and Zahran, M. and Zambon, M. and Zanella, A. and Zawadka, K. and Zayyad, H. and Zoufaly, A. and Zucman, D.},
month = {jun},
year = {2021},
abstract = {Background: The ISARIC prospective multinational observational study is the largest cohort of hospitalized patients with COVID-19. We present relationships of age, sex, and nationality to presenting symptoms. Methods: International, prospective observational study of 60 109 hospitalized symptomatic patients with laboratory-confirmed COVID-19 recruited from 43 countries between 30 January and 3 August 2020. Logistic regression was performed to evaluate relationships of age and sex to published COVID-19 case definitions and the most commonly reported symptoms. Results: ‘Typical’ symptoms of fever (69%), cough (68%) and shortness of breath (66%) were the most commonly reported. 92% of patients experienced at least one of these. Prevalence of typical symptoms was greatest in 30- to 60-year-olds (respectively 80, 79, 69%; at least one 95%). They were reported less frequently in children (≤ 18 years: 69, 48, 23; 85%), older adults (≥ 70 years: 61, 62, 65; 90%), and women (66, 66, 64; 90%; vs. men 71, 70, 67; 93%, each P &lt; 0.001). The most common atypical presentations under 60 years of age were nausea and vomiting and abdominal pain, and over 60 years was confusion. Regression models showed significant differences in symptoms with sex, age and country. Interpretation: This international collaboration has allowed us to report reliable symptom data from the largest cohort of patients admitted to hospital with COVID-19. Adults over 60 and children admitted to hospital with COVID-19 are less likely to present with typical symptoms. Nausea and vomiting are common atypical presentations under 30 years. Confusion is a frequent atypical presentation of COVID-19 in adults over 60 years. Women are less likely to experience typical symptoms than men.},
journal = {Infection},
publisher = {Springer Nature},
url = {http://dx.doi.org/10.1007/s15010-021-01599-5},
}
