@article{Pieretti_J-2020_45596,
title = {Nitric oxide (NO) and nanoparticles – Potential small tools for the war against COVID-19 and other human coronavirus infections},
author = {Pieretti, J. and Rubilar, O. and Weller, R. and Tortella, G. and Seabra, A.},
month = {oct},
year = {2020},
abstract = {The endogenous free radical nitric oxide (NO) plays a pivotal role in the immunological system. NO has already been reported as a potential candidate for use in the treatment of human coronavirus infections, including COVID-19. In fact, inhaled NO has been used in clinical settings for its antiviral respiratory action, and in the regulation of blood pressure to avoid clot formation. In this mini-review, we discuss recent progress concerning the antivirus activity of NO in clinical, pre-clinical and research settings, and its beneficial effects in the treat-ment of clinical complications in patients infected with coronaviruses and other respiratory viral diseases, including COVID-19. We also highlight promising therapeutic effects of NO donors allied to nanomaterials to combat COVID-19 and other human coronavirus infections. Nanomaterials can be designed to deliver sustained, localized NO release directly at the desired application site, enhancing the beneficial effects of NO and mini-mizing the side effects. Challenges and perspectives are presented to open new fields of research.},
volume = {291},
journal = {Virus Research},
publisher = {Elsevier},
url = {https://doi.org/10.1016/j.virusres.2020.198202},
}
