@article{Wei_J-2021_50499,
title = {Anti-spike antibody response to natural SARS-CoV-2 infection in the general population},
author = {Wei, J. and Matthews, P. and Stoesser, N. and Maddox, T. and Lorenzi, L. and Studley, R. and Bell, J. and Newton, J. and Farrar, J. and Diamond, I. and Rourke, E. and Howarth, A. and Marsden, B. and Hoosdally, S. and Jones, E. and Stuart, D. and Crook, D. and Peto, T. and Pouwels, K. and Walker, A. and Eyre, D. and team, C.},
month = {oct},
year = {2021},
abstract = {Understanding the trajectory, duration, and determinants of antibody responses after SARS-CoV-2 infection can inform subsequent protection and risk of reinfection, however large-scale representative studies are limited. Here we estimated antibody response after SARS-CoV-2 infection in the general population using representative data from 7,256 United Kingdom COVID-19 infection survey participants who had positive swab SARS-CoV-2 PCR tests from 26-April-2020 to 14-June-2021. A latent class model classified 24% of participants as ‘non-responders’ not developing anti-spike antibodies, who were older, had higher SARS-CoV-2 cycle threshold values during infection (i.e. lower viral burden), and less frequently reported any symptoms. Among those who seroconverted, using Bayesian linear mixed models, the estimated anti-spike IgG peak level was 7.3-fold higher than the level previously associated with 50% protection against reinfection, with higher peak levels in older participants and those of non-white ethnicity. The estimated anti-spike IgG half-life was 184 days, being longer in females and those of white ethnicity. We estimated antibody levels associated with protection against reinfection likely last 1.5-2 years on average, with levels associated with protection from severe infection present for several years. These estimates could inform planning for vaccination booster strategies.},
volume = {12},
journal = {Nature Communications},
publisher = {Springer Nature},
url = {https://doi.org/10.1038/s41467-021-26479-2},
}
