@article{Bell_S-2022_57930,
title = {The impact of vaccination on incidence and outcomes of SARS-CoV-2 infection in patients with kidney failure in Scotland},
author = {Bell, S. and Campbell, J. and Lambourg, E. and Watters, C. and O'Neil, M. and Almond, A. and Buck, K. and Carr, E. and Clark, L. and Cousland, Z. and Findlay, M. and Joss, N. and Metcalfe, W. and Petrie, M. and Spalding, E. and Traynor, J. and Sanu, V. and Thomson, P. and Methven, S. and Mark, P.},
month = {feb},
year = {2022},
abstract = {Background: Patients with kidney failure requiring kidney replacement therapy (KRT) are at high risk of complications and death following SARS-CoV-2 infection with variable antibody responses to vaccination reported. We investigated the effects of COVID-19 vaccination on incidence of infection, hospitalization and death of COVID-19 infection. Methods: Study design was an observational data linkage cohort study. Multiple healthcare datasets were linked to ascertain all SARS-CoV-2 testing, vaccination, hospitalization, and mortality data for all patients treated with KRT in Scotland, from the start of the pandemic over a period of 20 months. Descriptive statistics, survival analyses, and vaccine effectiveness were calculated. Results: As of 19th September 2021, 93% (n=5281) of the established KRT population in Scotland had received two doses of an approved SARS-CoV-2 vaccine. Over the study period, there were 814 cases of SARS-CoV-2 infection (15.1% of the KRT population). Vaccine effectiveness against infection and hospitalization was 33% (95% CI 0-52) and 38% (95% CI 0-57) respectively. 9.2% of fully vaccinated individuals died within 28 days of a SARS-CoV-2 positive PCR test (7% dialysis patients and 10% kidney transplant recipients). This compares to &lt;0.1% of the vaccinated Scottish population being admitted to hospital or dying death due to COVID19 during that period. Conclusions: These data demonstrate a primary vaccine course of two doses has limited impact on COVID-19 infection and its complications in patients treated with KRT. Adjunctive strategies to reduce risk of both COVID-19 infection and its complications in this population are urgently required.},
journal = {Journal of the American Society of Nephrology},
publisher = {American Society of Nephrology},
url = {http://dx.doi.org/10.1681/ASN.2022010046},
}
