@article{Liu_X-2021_64460,
title = {SARS-CoV-2 Causes a Significant Stress Response Mediated by Small RNAs in the Blood of COVID-19 Patients},
author = {Liu, X. and Wen, Y. and Huang, Z. and Shen, X. and Wang, J. and Luo, Y. and Chen, W. and Lun, Z. and Li, H. and Qu, L. and Shan, H. and Zheng, L.},
month = {dec},
year = {2021},
abstract = {SARS-CoV-2 has had a serious impact on the world. In this study, small RNAs from the blood of COVID-19 patients with moderate or severe symptoms were extracted for high-throughput sequencing and analysis. Interestingly, the levels of a special group of tRNA-derived small RNAs (tsRNAs) were found to be dramatically upregulated after SARS-CoV-2 infection, particularly in COVID-19 patients with severe symptoms. In particular, the 3'CCA tsRNAs from Gly-tRNA were highly consistent with the inflammation indicator C-reactive protein (CRP). In addition, we found that the majority of significantly changed microRNAs (miRNAs) were associated with endoplasmic reticulum (ER)/unfolded protein response (UPR) sensors, which may lead to the induction of proinflammatory cytokine and immune responses. This study found that SARS-CoV-2 infection caused significant changes in the levels of stress-associated small RNAs in patient blood and their potential functions. Our research revealed that the cells of COVID-19 patients undergo tremendous stress and respond, which can be reflected or regulated by sncRNAs, thus providing potential thought for therapeutic intervention in COVID-19 by modulating small RNA levels or activities.},
pages = {751-762},
volume = {27},
journal = {Molecular Therapy - Nucleic Acids},
publisher = {Elsevier},
url = {https://doi.org/10.1016/j.omtn.2021.12.034},
}
