@article{Gordon_D-2020_7230,
title = {Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms},
author = {Gordon, D. and Hiatt, J. and Bouhaddou, M. and Rezelj, V. and Ulferts, S. and Braberg, H. and Jureka, A. and Obernier, K. and Guo, J. and Batra, J. and Kaake, R. and Weckstein, A. and Owens, T. and Gupta, M. and Pourmal, S. and Titus, E. and Cakir, M. and Soucheray, M. and McGregor, M. and Cakir, Z. and Jang, G. and O'Meara, M. and Tummino, T. and Zhang, Z. and Foussard, H. and Rojc, A. and Zhou, Y. and Kuchenov, D. and Hüttenhain, R. and Xu, J. and Eckhardt, M. and Swaney, D. and Fabius, J. and Ummadi, M. and Tutuncuoglu, B. and Rathore, U. and Modak, M. and Haas, P. and Haas, K. and Williams, D. and Hastie, C. and Elliott, M. and Brown, F. and Burness, K. and Reid, E. and Baillie, C. and Raggett, S. and Toth, R. and Alessi, D. and Davies, P. and García-Sastre, A. and Rassen, J. and Grosse, R. and Rosenberg, O. and Verba, K. and Basler, C. and Vignuzzi, M. and Peden, A. and Beltrao, P. and Krogan, N.},
month = {dec},
year = {2020},
abstract = {The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a grave threat to public health and the global economy. SARS-CoV-2 is closely related to the more lethal but less transmissible coronaviruses SARS-CoV-1 and Middle East respiratory syndrome coronavirus (MERS-CoV). Here, we have carried out comparative viral-human proteinprotein interaction and viral protein localization analyses for all three viruses. Subsequent functional genetic screening identified host factors that functionally impinge on coronavirus proliferation, including Tom70, a mitochondrial chaperone protein that interacts with both SARS-CoV-1 and SARSCoV- 2 ORF9b, an interaction we structurally characterized using cryo-electron microscopy. Combining genetically validated host factors with both COVID-19 patient genetic data and medical billing records identified molecular mechanisms and potential drug treatments that merit further molecular and clinical study.},
volume = {370},
issue = {6521},
journal = {Science},
publisher = {American Association for the Advancement of Science},
url = {https://doi.org/10.1126/science.abe9403},
}
