@article{Dupont_L-2021_80801,
title = {Neutralizing antibody activity in convalescent sera from infection in humans with SARS-CoV-2 and variants of concern},
author = {Dupont, L. and Snell, L. and Graham, C. and Seow, J. and Merrick, B. and Lechmere, T. and Maguire, T. and Hallett, S. and Pickering, S. and Charalampous, T. and Alcolea-Medina, A. and Huettner, I. and Jimenez-Guardeño, J. and Acors, S. and Almeida, N. and Cox, D. and Dickenson, R. and Galao, R. and Kouphou, N. and Lista, M. and Ortega-Prieto, A. and Wilson, H. and Winstone, H. and Fairhead, C. and Su, J. and Nebbia, G. and Batra, R. and Neil, S. and Shankar-Hari, M. and Edgeworth, J. and Malim, M. and Doores, K.},
month = {oct},
year = {2021},
abstract = {COVID-19 vaccine design and vaccination rollout need to take into account a detailed understanding of antibody durability and cross-neutralizing potential against SARS-CoV-2 and emerging variants of concern (VOCs). Analyses of convalescent sera provide unique insights into antibody longevity and cross-neutralizing activity induced by variant spike proteins, which are putative vaccine candidates. Using sera from 38 individuals infected in wave 1, we show that cross-neutralizing activity can be detected up to 305 days pos onset of symptoms, although sera were less potent against B.1.1.7 (Alpha) and B1.351 (Beta). Over time, despite a reduction in overall neutralization activity, differences in sera neutralization potency against SARS-CoV-2 and the Alpha and Beta variants decreased, which suggests that continued antibody maturation improves tolerance to spike mutations. We also compared the cross-neutralizing activity of wave 1 sera with sera from individuals infected with the Alpha, the Beta or the B.1.617.2 (Delta) variants up to 79 days post onset of symptoms. While these sera neutralize the infecting VOC and parental virus to similar levels, cross-neutralization of different SARS-CoV-2 VOC lineages is reduced. These findings will inform the optimization of vaccines to protect against SARS-CoV-2 variants.},
pages = {1433-1442},
volume = {6},
issue = {11},
journal = {Nature Microbiology},
publisher = {Springer Nature},
url = {https://doi.org/10.1038/s41564-021-00974-0},
}
