@article{Bruce_E-2020_8168,
title = {Prior Routine use of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) and Important Outcomes in Hospitalised Patients with COVID-19},
author = {Bruce, E. and Barlow-Pay, F. and Short, R. and Vilches-Moraga, A. and Price, A. and McGovern, A. and Braude, P. and Stechman, M. and Moug, S. and McCarthy, K. and Hewitt, J. and Carter, B. and Myint, P.},
month = {aug},
year = {2020},
abstract = {Coronavirus disease 2019 (COVID-19) infection causes acute lung injury, resulting from aggressive inflammation initiated by viral replication. There has been much speculation about the potential role of non-steroidal inflammatory drugs (NSAIDs), which increase the expression of angiotensin-converting enzyme 2 (ACE2), a binding target for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to enter the host cell, which could lead to poorer outcomes in COVID-19 disease.  The aim of this study was to examine the association between routine use of NSAIDs and outcomes in hospitalised patients with COVID-19. This was a multicentre, observational study, with data collected from adult patients with COVID-19 admitted to eight UK hospitals. Of 1222 patients eligible to be included, 54 (4.4%) were routinely prescribed NSAIDs prior to admission. Univariate results suggested a modest protective effect from the use of NSAIDs, but in the multivariable analysis, there was no association between prior NSAID use and time to mortality (adjusted HR (aHR) = 0.89, 95% CI 0.52–1.53,p= 0.67) or length of stay (aHR 0.89, 95% CI 0.59–1.35,p= 0.58).  This study found no evidence that routine NSAID use was associated with higher COVID-19 mortality in hospitalised patients; therefore, patients should be advised to continue taking these medications until further evidence emerges. Our findings suggest that NSAID use might confer a modest benefit with regard to survival. However, as this finding was underpowered, further research is required.},
volume = {9},
issue = {8},
journal = {Journal of Clinical Medicine},
publisher = {MDPI},
url = {https://doi.org/10.3390/jcm9082586},
}
