@article{Yang_Z-2022_83044,
title = {Genetic landscape of the ACE2 coronavirus receptor},
author = {Yang, Z. and MacDonald-Dunlop, E. and Chen, J. and Zhai, R. and Li, T. and Richmond, A. and Klaric, L. and Pirastu, N. and Ning, Z. and Zheng, C. and Wang, Y. and Huang, T. and He, Y. and Guo, H. and Ying, K. and Gustafsson, S. and Prins, B. and Ramisch, A. and Dermitzakis, E. and Png, G. and Eriksson, N. and Haessler, J. and Hu, X. and Zanetti, D. and Boutin, T. and Hwang, S. and Wheeler, E. and Pietzner, M. and Raffield, L. and Kalnapenkis, A. and Peters, J. and Viñuela, A. and Gilly, A. and Elmståhl, S. and Dedoussis, G. and Petrie, J. and Polašek, O. and Folkersen, L. and Chen, Y. and Yao, C. and Võsa, U. and Pairo-Castineira, E. and Clohisey, S. and Bretherick, A. and Rawlik, K. and Esko, T. and Enroth, S. and Johansson, Å. and Gyllensten, U. and Langenberg, C. and Levy, D. and Hayward, C. and Assimes, T. and Kooperberg, C. and Manichaikul, A. and Siegbahn, A. and Wallentin, L. and Lind, L. and Zeggini, E. and Schwenk, J. and Butterworth, A. and Michaëlsson, K. and Pawitan, Y. and Joshi, P. and Baillie, J. and Mälarstig, A. and Reiner, A. and Wilson, J. and Shen, X.},
month = {apr},
year = {2022},
abstract = {Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiologic agent of COVID-19, enters human cells using the angiotensin-converting enzyme 2 (ACE2) protein as a receptor. ACE2 is thus key to the infection and treatment of the coronavirus. ACE2 is highly expressed in the heart, respiratory and gastrointestinal tracts, playing important regulatory roles in the cardiovascular and other biologic systems. However, the genetic basis of the ACE2 protein levels is not well understood.},
pages = {1398-1411},
volume = {145},
issue = {18},
journal = {Circulation},
publisher = {Wolters Kluwer},
url = {https://doi.org/10.1161/CIRCULATIONAHA.121.057888},
}
