@article{Wilkinson_S-2022_87355,
title = {Recurrent SARS-CoV-2 Mutations in Immunodeficient Patients [pre-print]},
author = {Wilkinson, S. and Richter, A. and Casey, A. and Osman, H. and Mirza, J. and Stockton, J. and Quick, J. and Ratcliffe, L. and Sparks, N. and Cumley, N. and Poplawski, R. and Nicholls, S. and Kele, B. and Harris, K. and COVID-19 Genomics UK (COG-UK) consortium and Peacock, T. and Loman, N.},
month = {mar},
year = {2022},
abstract = {Long-term SARS-CoV-2 infections in immunodeficient patients are an important source of variation for the virus but are understudied. Many case studies have been published which describe one or a small number of long-term infected individuals but no study has combined these sequences into a cohesive dataset. This work aims to rectify this and study the genomics of this patient group through a combination of literature searches as well as identifying new case series directly from the COG-UK dataset. The spike gene receptor binding domain (RBD) and N-terminal domains (NTD) were identified as mutation hotspots. Numerous mutations associated with variants of concern were observed to emerge recurrently. Additionally a mutation in the envelope gene, - T30I was determined to be the most recurrent frequently occurring mutation arising in persistent infections. A high proportion of recurrent mutations in immunodeficient individuals are associated with ACE2 affinity, immune escape, or viral packaging optimisation.},
journal = {medRxiv},
publisher = {medRxiv},
url = {https://doi.org/10.1101/2022.03.02.22271697},
}
