@article{Kemp_S-2022_88473,
title = {Transmission of B.1.617.2 Delta variant between vaccinated healthcare workers},
author = {Kemp, S. and Cheng, M. and Hamilton, W. and Kamelian, K. and Chauhan, H. and Dikid, T. and Gogia, H. and Lall, H. and Ponnusamy, K. and Verma, K. and Dhar, M. and Singh, M. and Datta, M. and Soni, N. and Meena, N. and Madan, P. and Singh, P. and Sharma, R. and Sharma, R. and Kabra, S. and Kumar, S. and Kumari, S. and Sharma, U. and Chaudhary, U. and Sivasubbu, S. and Scaria, V. and Wattal, C. and Oberoi, J. and Raveendran, R. and Datta, S. and Das, S. and Maitra, A. and Chinnaswamy, S. and Biswas, N. and Parida, A. and Raghav, S. and Prasad, P. and Sarin, A. and Mayor, S. and Ramakrishnan, U. and Palakodeti, D. and Seshasayee, A. and Thangaraj, K. and Bashyam, M. and Dalal, A. and Bhat, M. and Shouche, Y. and Pillai, A. and Abraham, P. and Potdar, V. and Cherian, S. and Desai, A. and Pattabiraman, C. and Manjunatha, M. and Mani, R. and Udupi, G. and Nandicoori, V. and Tallapaka, K. and Sowpati, D. and Singh, S. and Rakshit, P. and Agrawal, A. and Illingworth, C. and Gupta, R.},
month = {jun},
year = {2022},
abstract = {Breakthrough infections with SARS-CoV-2 Delta variant have been reported in doubly-vaccinated recipients and as re-infections. Studies of viral spread within hospital settings have highlighted the potential for transmission between doubly-vaccinated patients and health care workers and have highlighted the benefits of high-grade respiratory protection for health care workers. However the extent to which vaccination is preventative of viral spread in health care settings is less well studied. Here, we analysed data from 118 vaccinated health care workers (HCW) across two hospitals in India, constructing two probable transmission networks involving six HCWs in Hospital A and eight HCWs in Hospital B from epidemiological and virus genome sequence data, using a suite of computational approaches. A maximum likelihood reconstruction of transmission involving known cases of infection suggests a high probability that doubly vaccinated HCWs transmitted SARS-CoV-2 between each other and highlights potential cases of virus transmission between individuals who had received two doses of vaccine. Our findings show firstly that vaccination may reduce rates of transmission, supporting the need for ongoing infection control measures even in highly vaccinated populations, and secondly we have described a novel approach to identifying transmissions that is scalable and rapid, without the need for an infection control infrastructure.},
volume = {12},
issue = {1},
journal = {Scientific Reports},
publisher = {Springer Nature},
url = {http://dx.doi.org/10.1038/s41598-022-14411-7},
}
