@article{Gualano_B-2022_89092,
title = {Physical activity and antibody persistence 6 months after the second dose of coronavac in immunocompromised patients.},
author = {Gualano, B. and Lemes, Í. and da Silva, R. and Pinto, A. and Mazzolani, B. and Smaira, F. and Sieczkowska, S. and Aikawa, N. and Pasoto, S. and Medeiros-Ribeiro, A. and Saad, C. and Yuk, E. and Silva, C. and Swinton, P. and Hallal, P. and Roschel, H. and Bonfa, E.},
month = {jul},
year = {2022},
abstract = {This prospective cohort study within an open-label, single-arm, phase 4 vaccination trial (clinicaltrials.gov #NCT04754698) aimed to investigate the association between physical activity and persistent anti-SARS-CoV-2 antibodies 6 months after two-dose schedule of CoronaVac in autoimmune rheumatic diseases (ARD) patients (n=748). Persistent immunogenicity 6 months after the full-course vaccination was assessed using seroconversion rates of total anti-SARS-CoV-2 S1/S2 IgG, geometric mean titers of anti-S1/S2 IgG (GMT), and frequency of positive neutralizing antibodies (NAb). Physical activity was assessed trough questionnaire. Adjusted point estimates from logistic regression models indicated greater odds of seroconversion rates (OR: 1.5 [95%CI: 1.1 to 2.1]) and NAb positivity (OR: 1.5 [95%CI: 1.0 to 2.1]) in physically active patients and approximately 43% greater GMT (42.8% [95%CI: 11.9 to 82.2]) than inactive ones. In conclusion, among immunocompromised patients, being physically active was associated with an increment in antibody persistence through 6 months after a full-course of an inactivated SARS-CoV-2 vaccine.},
journal = {Scandinavian Journal of Medicine and Science in Sports},
publisher = {Wiley},
url = {https://doi.org/10.1111/sms.14213},
}
