@article{Velu_P-2021_94878,
title = {Post-mortem dissection of COVID-19: a pathogenic role for macrophages?},
author = {Velu, P. and Lucas, C. and Conway Morris, A.},
month = {sep},
year = {2021},
abstract = {Acute respiratory failure is the leading cause of death in severe COVID-19. By combining rapid tissue sampling at autopsy with high dimensional analyses, including measurement of immune cells, proteins and RNA, unparalleled insights into the mechanisms of dysregulated inflammation in COVID-19 have been obtained. Here we summarise some of the conceptual advances revealed by post-mortem studies of severe COVID-19, and make particular reference to the apparent dominance of macrophages, how this may relate to disease pathophysiology, and the opportunities for targeted therapeutic intervention.},
pages = {1322-1325},
volume = {47},
issue = {11},
journal = {Intensive Care Medicine},
publisher = {Springer Nature},
url = {https://doi.org/10.1007/s00134-021-06509-9},
}
