@article{Bousquet_J-2020_9620,
title = {Spices to Control COVID-19 Symptoms: Yes, but Not Only…},
author = {Bousquet, J. and Czarlewski, W. and Zuberbier, T. and Mullol, J. and Blain, H. and Cristol, J. and De La Torre, R. and Le Moing, V. and Pizarro Lozano, N. and Bedbrook, A. and Agache, I. and Akdis, C. and Canonica, G. and Cruz, A. and Fiocchi, A. and Fonseca, J. and Fonseca, S. and Gemicioğlu, B. and Haahtela, T. and Iaccarino, G. and Ivancevich, J. and Jutel, M. and Klimek, L. and Kuna, P. and Larenas-Linnemann, D. and Melén, E. and Okamoto, Y. and Papadopoulos, N. and Pfaar, O. and Reynes, J. and Rolland, Y. and Rouadi, P. and Samolinski, B. and Sheikh, A. and Toppila-Salmi, S. and Valiulis, A. and Choi, H. and Kim, H. and Antó, J.},
month = {dec},
year = {2020},
abstract = {There are large country variations in COVID-19 death rates that may be partly explained by diet. Many countries with low COVID-19 death rates have a common feature of eating large quantities of fermented vegetables such as cabbage and, in some continents, various spices. Fermented vegetables and spices are agonists of the antioxidant transcription factor nuclear factor (erythroid-derived 2)-like 2 (Nrf2), and spices are transient receptor potential ankyrin 1 and vanillin 1 (TRPA1/V1) agonists. These mechanisms may explain many COVID-19 symptoms and severity. It appears that there is a synergy between Nrf2 and TRPA1/V1 foods that may explain the role of diet in COVID-19. One of the mechanisms of COVID-19 appears to be an oxygen species (ROS)-mediated process in synergy with TRP channels, modulated by Nrf2 pathways. Spicy foods are likely to desensitize TRP channels and act in synergy with exogenous antioxidants that activate the Nrf2 pathway.},
pages = {489-495},
volume = {182},
issue = {6},
journal = {International Archives of Allergy and Immunology},
publisher = {S. Karger AG},
url = {https://doi.org/10.1159/000513538},
}
