@article{Aati_H-2022_97808,
title = {Garcinia cambogia phenolics as potent anti-COVID-19 agents: phytochemical profiling, biological activities, and molecular docking},
author = {Aati, H. and Ismail, A. and Rateb, M. and AboulMagd, A. and Hassan, H. and Hetta, M.},
month = {sep},
year = {2022},
abstract = {COVID-19 is a disease caused by the coronavirus SARS-CoV-2 and became a pandemic in a critically short time. Phenolic secondary metabolites attracted much attention from the pharmaceutical industries for their easily accessible natural sources and proven antiviral activity. In our mission, a metabolomics study of the Garcinia cambogia Roxb. fruit rind was performed using LC-HRESIMS to investigate its chemical profile, especially the polar aspects, followed by a detailed phytochemical analysis, which led to the isolation of eight known compounds. Using spectrometric techniques, the isolated compounds were identified as quercetin, amentoflavone, vitexin, rutin, naringin, catechin, p-coumaric, and gallic acids. The antiviral activities of the isolated compounds were investigated using two assays; the 3CL-Mproenzyme showed that naringin had a potent effect with IC5016.62 μg/mL, followed by catechin and gallic acid (IC5026.2, 30.35 μg/mL, respectively), while the direct antiviral inhibition effect of naringin confirmed the potency with an EC50of 0.0169 μM. To show the molecular interaction, in situ molecular docking was carried out using a COVID-19 protease enzyme. Both biological effects and docking studies showed the hydrophobic interactions with Gln 189 or Glu 166, per the predicated binding pose of the isolated naringin.},
volume = {11},
issue = {19},
journal = {Plants},
publisher = {MDPI},
url = {https://doi.org/10.3390/plants11192521},
}
