@article{Calvert_C-2022_99043,
title = {A population-based matched cohort study of early pregnancy outcomes following COVID-19 vaccination and SARS-CoV-2 infection},
author = {Calvert, C. and Carruthers, J. and Denny, C. and Donaghy, J. and Hillman, S. and Hopcroft, L. and Hopkins, L. and Goulding, A. and Lindsay, L. and McLaughlin, T. and Moore, E. and Pan, J. and Taylor, B. and Almaghrabi, F. and Auyeung, B. and Bhaskaran, K. and Gibbons, C. and Katikireddi, S. and McCowan, C. and Murray, J. and O'Leary, M. and Ritchie, L. and Shah, S. and Simpson, C. and Robertson, C. and Sheikh, A. and Stock, S. and Wood, R.},
month = {oct},
year = {2022},
abstract = {Data on the safety of COVID-19 vaccines in early pregnancy are limited. We conducted a national, population-based, matched cohort study assessing associations between COVID-19 vaccination and miscarriage prior to 20 weeks gestation and, separately, ectopic pregnancy. We identified women in Scotland vaccinated between 6 weeks preconception and 19 weeks 6 days gestation (for miscarriage; n = 18,780) or 2 weeks 6 days gestation (for ectopic; n = 10,570). Matched, unvaccinated women from the pre-pandemic and, separately, pandemic periods were used as controls. Here we show no association between vaccination and miscarriage (adjusted Odds Ratio [aOR], pre-pandemic controls = 1.02, 95% Confidence Interval [CI] = 0.96–1.09) or ectopic pregnancy (aOR = 1.13, 95% CI = 0.92–1.38). We undertook additional analyses examining confirmed SARS-CoV-2 infection as the exposure and similarly found no association with miscarriage or ectopic pregnancy. Our findings support current recommendations that vaccination remains the safest way for pregnant women to protect themselves and their babies from COVID-19.},
volume = {13},
journal = {Nature Communications},
publisher = {Springer Nature},
url = {https://doi.org/10.1038/s41467-022-33937-y},
}
