TY - JOUR
AU - Tibble, Holly
AU - Mueller, Tanja
AU - Proud, Euan
AU - Hall, Elliott
AU - Kurdi, Amanj
AU - Robertson, Chris
AU - Bennie, Marion
AU - Woolford, Lana
AU - Sheikh, Aziz
PY - 2022
DA - November
TI - Uptake of monoclonal antibodies and anti-viral therapies for COVID-19 in Scotland
JO - The Lancet
AB - SARS-CoV-2 has constantly been evolving since it was first detected in 2019. Virus mutations have impacted on transmissibility, virulence, and the effectiveness of vaccines and COVID-19 therapeutics. In Scotland, treatments recently made available for use in patients with COVID-19 are Sotrovimab, a neutralising monoclonal antibody (mAB) that specifically target SARS-CoV-2 spike proteins, and the SARS-CoV-2-specific antiviral drugs nirmatrelvir/ritonavir (Paxlovid) and molnupiravir, which inhibit viral replication by inhibiting viral protease and by increasing viral RNA mutagenesis. Current guidance is that these should be offered to vulnerable patients within five to seven days of presenting with mild-to-moderate COVID-19 to prevent disease progression.[1] Choice of treatment is mainly determined based on pre-existing conditions and/or concurrent drug treatment. Other more established therapeutics are also used in an in-patient setting to improve outcomes in hospitalised patients with severe COVID-19.[2]
PB - Elsevier
UR - https://strathprints.strath.ac.uk/83314/
KW - Coronavirus (COVID-19)
ER