TY - JOUR
AU - Curtis, Helen J.
AU - Inglesby, Peter
AU - Morton, Caroline E.
AU - Mackenna, Brian
AU - Green, Amelia C.A.
AU - Hulme, William
AU - Walker, Alex J.
AU - Morley, Jessica
AU - Mehrkar, Amir
AU - Bacon, Sebastian C.J.
AU - Hickman, George
AU - Bates, Chris J.
AU - Croker, Richard
AU - Evans, David
AU - Ward, Tom
AU - Cockburn, Jonathan
AU - Davy, Simon
AU - Bhaskaran, Krishnan
AU - Schultze, Anna
AU - Rentsch, Christopher T.
AU - Williamson, Elizabeth J.
AU - Rowan, Anna
AU - Fisher, Louis
AU - McDonald, Helen I.
AU - Tomlinson, Laurie
AU - Mathur, Rohini
AU - Drysdale, Henry
AU - Eggo, Rosalind M.
AU - Wing, Kevin
AU - Wong, Angel Y.S.
AU - Forbes, Harriet
AU - Parry, John
AU - Hester, Frank
AU - Harper, Sam
AU - O'Hanlon, Shaun
AU - Eavis, Alex
AU - Jarvis, Richard
AU - Avramov, Dima
AU - Griffiths, Paul
AU - Fowles, Aaron
AU - Parkes, Nasreen
AU - Douglas, Ian J.
AU - Evans, Stephen J.W.
AU - Smeeth, Liam
AU - Goldacre, Ben
AU - The OpenSAFELY Collaborative
PY - 2021
DA - December
TI - Trends and clinical characteristics of COVID-19 vaccine recipients: A federated analysis of 57.9 million patients' primary care records in situ using OpenSAFELY
JO - British Journal of General Practice
EP - e62
VL - 72
IS - 714
DO - https://doi.org/10.3399/BJGP.2021.0376
AB - Background On 8 December 2020 NHS England administered the first COVID-19 vaccination. Aim To describe trends and variation in vaccine coverage in different clinical and demographic groups in the first 100 days of the vaccine rollout. Design and setting With the approval of NHS England, a cohort study was conducted of 57.9 million patient records in general practice in England, in situ and within the infrastructure of the electronic health record software vendors EMIS and TPP using OpenSAFELY. Method Vaccine coverage across various subgroups of Joint Committee on Vaccination and Immunisation (JCVI) priority cohorts is described. Results A total of 20 852 692 patients (36.0%) received a vaccine between 8 December 2020 and 17 March 2021. Of patients aged ≥80 years not in a care home (JCVI group 2) 94.7% received a vaccine, but with substantial variation by ethnicity (White 96.2%, Black 68.3%) and deprivation (least deprived 96.6%, most deprived 90.7%). Patients with pre-existing medical conditions were more likely to be vaccinated with two exceptions: severe mental illness (89.5%) and learning disability (91.4%). There were 275 205 vaccine recipients who were identified as care home residents (JCVI group 1; 91.2% coverage). By 17 March, 1 257 914 (6.0%) recipients had a second dose. Conclusion The NHS rapidly delivered mass vaccination. In this study a data-monitoring framework was deployed using publicly auditable methods and a secure in situ processing model, using linked but pseudonymised patient-level NHS data for 57.9 million patients. Targeted activity may be needed to address lower vaccination coverage observed among certain key groups.
PB - Royal College of General Practitioners
UR - https://www.research.ed.ac.uk/en/publications/b78032e1-2147-4d0e-8dc9-f4e4e421d2d7
KW - Coronavirus (COVID-19)
KW - Immunisation and screening
KW - Primary care
ER