TY - JOUR
AU - Cevik, Muge
AU - Kuppalli, Krutika
AU - Kindrachuk, Jason
AU - Peiris, Malik
PY - 2020
DA - October
TI - Virology, transmission, and pathogenesis of SARS-CoV-2
JO - BMJ
VL - 371
IS - 8267
DO - https://doi.org/10.1136/bmj.m3862
AB - What you need to knowSARS-CoV-2 is genetically similar to SARS-CoV-1, but characteristics of SARS-CoV-2—eg, structural differences in its surface proteins and viral load kinetics—may help explain its enhanced rate of transmissionIn the respiratory tract, peak SARS-CoV-2 load is observed at the time of symptom onset or in the first week of illness, with subsequent decline thereafter, indicating the highest infectiousness potential just before or within the first five days of symptom onsetReverse transcription polymerase chain reaction (RT-PCR) tests can detect viral SARS-CoV-2 RNA in the upper respiratory tract for a mean of 17 days; however, detection of viral RNA does not necessarily equate to infectiousness, and viral culture from PCR positive upper respiratory tract samples has been rarely positive beyond nine days of illnessSymptomatic and pre-symptomatic transmission (1-2 days before symptom onset), is likely to play a greater role in the spread of SARS-CoV-2 than asymptomatic transmissionA wide range of virus-neutralising antibodies have been reported, and emerging evidence suggests that these may correlate with severity of illness but wane over time
PB - BMJ Publishing Group
UR - http://hdl.handle.net/10023/20940
KW - Coronavirus (COVID-19)
ER