TY - JOUR
AU - Purshouse, Karin
AU - Thomson, John P
AU - Vallet, Mahéva
AU - Alexander, Lorna
AU - Bonisteel, Isaac
AU - Brennan, Maree
AU - Cameron, David
AU - Figueroa, Jonine D.
AU - Furrie, Elizabeth
AU - Haig, Pamela
AU - Heck, Mattea
AU - McCaughan, Hugh
AU - Mitchell, Paul
AU - Mcvicars, Heather
AU - Primrose, Lorraine
AU - Silva, Ines L.
AU - Templeton, Kate
AU - Wilson, Natalie
AU - Hall, Peter S.
PY - 2023
DA - January
TI - The Scottish COVID Cancer Immunity Prevalence Study: A Longitudinal Study of SARS-CoV-2 Immune Response in Patients Receiving Anti–Cancer Treatment
JO - The Oncologist
DO - https://doi.org/10.1093/oncolo/oyac257
AB - Background Cancer and anti-cancer treatment (ACT) may be risk factors for severe SARS-CoV-2 infection and limited vaccine efficacy. Long–term longitudinal studies are needed to evaluate these risks. The Scottish COVID cancer immunity prevalence (SCCAMP) study characterizes the incidence and outcomes of SARS-CoV-2 infection and vaccination in patients with solid tumors undergoing ACT. This preliminary analysis includes 766 patients recruited since May 2020. Methods Patients with solid-organ cancers attending secondary care for active ACT consented to the collection of routine electronic health record data and serial blood samples over 12 months. Blood samples were tested for total SARS-CoV-2 antibody. Results A total of 766 participants were recruited between May 28, 2020 and October 31, 2021. Most received cytotoxic chemotherapy (79%). Among the participants, 48 (6.3%) were tested positive for SARS-CoV-2 by PCR. Infection rates were unaffected by ACT, largely aligning with the local population. Mortality proportion was not higher with a recent positive SARS-CoV-2 PCR (10.4% vs 10.6%). Multivariate analysis revealed lower infection rates in vaccinated patients regardless of chemotherapy (HR 0.307 [95% CI, 0.144-0.6548]) or immunotherapy (HR 0.314 [95% CI, 0.041-2.367]) treatment. A total of 96.3% of patients successfully raised SARS-CoV-2 antibodies after &gt;2 vaccines. This was independent of the treatment type. Conclusion This is the largest on-going longitudinal real-world dataset of patients undergoing ACT during the early stages of the COVID-19 pandemic. This preliminary analysis demonstrates that patients with solid tumors undergoing ACT have high protection from SARS-CoV-2 infection following COVID-19 vaccination. The SCCAMP study will evaluate long–term COVID-19 antibody trends, focusing on specific ACTs and patient subgroups.
PB - Oxford University Press
UR - https://www.research.ed.ac.uk/en/publications/96cbfc26-a529-4222-89a5-aea98d22dc52
KW - Coronavirus (COVID-19)
KW - Immunisation and screening
ER