TY - JOUR
AU - Kurdi, Amanj
AU - Platt, Niketa
AU - Morrison, Aidan
AU - Proud, Euan
AU - Gronkowski, Karen
AU - Mueller, Tanja
AU - Seaton, R. Andrew
AU - Malcolm, William
AU - Bennie, Marion
PY - 2023
DA - February
TI - Evaluation of duration of antibiotic therapy across hospitals in Scotland including the impact of COVID-19 pandemic: a segmented interrupted time series analysis
JO - Expert Review of Anti-infective Therapy
AB - Background: Little is known about the duration of antibiotic use in hospital settings. We evaluated the duration of hospital antibiotic therapy (as a quality indicator proxy) for four commonly prescribed antibiotics (amoxicillin, co-amoxiclav, doxycycline and flucloxacillin) including the assessment of COVID-19 impact. Research design/methods: A repeated, cross-sectional study using the Hospital Electronic Prescribing and Medicines Administration system (January/2019-March/2022). Monthly median duration of therapy/duration categories were calculated, stratified by routes of administration, age and sex. Impact of COVID-19 was assessed using segmented time-series analysis. Results: There were significant variations in the median duration of therapy across routes of administration (P 7 days compared to oral or IV. Duration of therapy overall differed significantly by age. Some small statistically significant changes in the level/trends of duration of therapy were observed in the post- COVID-19 period. Conclusions: No evidence for prolonged duration of therapy were observed, even during COVID-19 pandemic. Duration of IV therapy was relatively short suggesting timely clinical review and consideration of IV to oral switch. Longer duration of therapy was observed among older patients.
PB - Taylor and Francis
UR - https://strathprints.strath.ac.uk/84086/
KW - Coronavirus (COVID-19)
KW - Hospital care
ER