TY - JOUR
AU - Hamilton, Fergus
AU - Thomas, Matt
AU - Arnold, David
AU - Palmer, Tom
AU - Moran, Ed
AU - Mentzer, Alexander J.
AU - Maskell, Nick
AU - Baillie, J. Kenneth
AU - Summers, Charlotte
AU - Hingorani, Aroon
AU - MacGowan, Alasdair
AU - Khandaker, Golam M
AU - Mitchell, Ruth E.
AU - George Davey Smith
AU - Ghazal, Peter
AU - Timpson, Nicholas J
PY - 2023
DA - January
TI - Therapeutic potential of IL6R blockade for the treatment of sepsis and sepsis-related death: A mendelian randomisation study
JO - PLoS Medicine
VL - 20
IS - 1
DO - https://doi.org/10.1371/journal.pmed.1004174
AB - BACKGROUND: Sepsis is characterised by dysregulated, life-threatening immune responses, which are thought to be driven by cytokines such as interleukin 6 (IL-6). Genetic variants in IL6R known to down-regulate IL-6 signalling are associated with improved Coronavirus Disease 2019 (COVID-19) outcomes, a finding later confirmed in randomised trials of IL-6 receptor antagonists (IL6RAs). We hypothesised that blockade of IL6R could also improve outcomes in sepsis.
PB - Public Library of Science
UR - https://www.research.ed.ac.uk/en/publications/af94e13c-8a1c-484d-a68d-fe1bf9611035
KW - Coronavirus (COVID-19)
ER