TY - JOUR
AU - Desai, Aamod Vikas
AU - Vornholt, Simon M.
AU - Major, Louise L
AU - Ettlinger, Romy
AU - Jansen, Christian
AU - Rainer, Daniel
AU - de Rome, Richard
AU - So, Venus
AU - Wheatley, Paul S.
AU - Edward, Ailsa K.
AU - Elliott, Caroline
AU - Pramanik, Atin
AU - Karmakar, Avishek
AU - Armstrong, Robert
AU - Janiak, Christoph
AU - Smith, Terry K
AU - Morris, Russell Edward
PY - 2023
DA - February
TI - Surface functionalized metal-organic frameworks for binding coronavirus proteins
JO - ACS Applied Materials & Interfaces
EP - 9065
VL - 15
IS - 7
DO - https://doi.org/10.1021/acsami.2c21187
AB - Since the outbreak of SARS-CoV-2, a multitude of strategies have been explored for the means of protection and shielding against virus particles: filtration equipment (PPE) has been widely used in daily life. In this work, we explore another approach in the form of deactivating coronavirus particles through selective binding onto the surface of metal–organic frameworks (MOFs) to further the fight against the transmission of respiratory viruses. MOFs are attractive materials in this regard, as their rich pore and surface chemistry can easily be modified on demand. The surfaces of three MOFs, UiO-66(Zr), UiO-66-NH2(Zr), and UiO-66-NO2(Zr), have been functionalized with repurposed antiviral agents, namely, folic acid, nystatin, and tenofovir, to enable specific interactions with the external spike protein of the SARS virus. Protein binding studies revealed that this surface modification significantly improved the binding affinity toward glycosylated and non-glycosylated proteins for all three MOFs. Additionally, the pores for the surface-functionalized MOFs can adsorb water, making them suitable for locally dehydrating microbial aerosols. Our findings highlight the immense potential of MOFs in deactivating respiratory coronaviruses to be better equipped to fight future pandemics.
PB - ACS Publications
UR - http://hdl.handle.net/10023/26979
KW - Coronavirus (COVID-19)
ER