TY - JOUR
AU - Sinclair, Lucy G.
AU - Ilieva, Zornitsa
AU - Morris, Georgina
AU - Anderson, John G.
AU - MacGregor, Scott J.
AU - Maclean, Michelle
PY - 2023
DA - March
TI - Viricidal efficacy of a 405-nm environmental decontamination system for inactivation of bacteriophage Phi6: surrogate for SARS-CoV-2
JO - Photochemistry and Photobiology
DO - https://doi.org/10.1111/php.13798 10.1111/php.13798
AB - The highly transmittable nature of SARS-CoV-2 has increased the necessity for novel strategies to safely decontaminate public areas. This study investigates the efficacy of a low irradiance 405-nm light environmental decontamination system for the inactivation of bacteriophage phi6 as a surrogate for SARS-CoV-2. Bacteriophage phi6 was exposed to increasing doses of low irradiance (~0.5 mW cm-2) 405-nm light whilst suspended in SM buffer and artificial human saliva at low (~103-4 PFU mL-1) and high (~107-8 PFU mL-1) seeding densities, to determine system efficacy for SARS-CoV-2 inactivation and establish the influence of biologically-relevant suspension media on viral susceptibility. Complete/near-complete (≥99.4%) inactivation was demonstrated in all cases, with significantly enhanced reductions observed in biologically-relevant media (P
PB - Wiley
UR - https://strathprints.strath.ac.uk/84632/
KW - Coronavirus (COVID-19)
ER