TY - JOUR
AU - Alvergne, Alexandra
AU - Kountourides, Gabriella
AU - Argentieri, M. Austin
AU - Agyen, Lisa
AU - Rogers, Natalie
AU - Knight, Dawn
AU - Sharp, Gemma C
AU - Maybin, Jacqueline A
AU - Olszewska, Zuzanna
PY - 2023
DA - March
TI - A retrospective case-control study on menstrual cycle changes following COVID-19 vaccination and disease
JO - iScience
DO - https://doi.org/10.1016/j.isci.2023.106401
AB - There has been increasing public concern that COVID-19 vaccination causes menstrual disturbance regarding the relative effect of vaccination compared to SARS-CoV-2 infection. Our objectives were to test potential risk factors for reporting menstrual cycle changes following COVID-19 vaccination and to compare menstrual parameters following COVID-19 vaccination and COVID-19 disease. We performed a secondary analysis of a retrospective online survey conducted in the UK in March 2021. In pre-menopausal vaccinated participants (n=4,989), 18% reported menstrual cycle changes after their first COVID-19 vaccine injection. The prevalence of reporting any menstrual changes was higher for women who smoke, have a history of COVID-19 disease, or are not using oestradiol-containing contraceptives. In a second sample including both vaccinated and unvaccinated participants (n=12,579), COVID-19 vaccination alone was not associated with abnormal menstrual cycle parameters while a history of COVID-19 disease was associated with an increased risk of reporting heavier bleeding, ‘missed’ periods and inter-menstrual bleeding.
PB - Elsevier
UR - https://www.research.ed.ac.uk/en/publications/7619d946-9470-444d-bdd1-94d3e3040a19
KW - Coronavirus (COVID-19)
ER