TY - JOUR
AU - Baillie, J. Kenneth
AU - Digard, Paul
AU - Goldswain, Hannah
AU - Dong, Xiaofeng
AU - Penrice-Randal, Rebekah
AU - Alruwaili, Muhannad
AU - Shawli, Ghada
AU - Prince, Tessa
AU - Williamson, Maia Kavanagh
AU - Raghwani, Jayna
AU - Randle, Nadine P.
AU - Jones, Benjamin
AU - Donovan-Banfield, I'ah
AU - Salguero, Francisco J.
AU - Tree, Julia
AU - Hall, Yper
AU - Hartley, Catherine S.
AU - Erdmann, Maximilium
AU - Bazire, James
AU - Jearanaiwitayakul, Tuksin
AU - Semple, Malcolm G.
AU - Openshaw, Peter J.M.
AU - ISARIC4C Investigators
AU - Emmett, Steven R.
AU - Matthews, David A.
AU - Turtle, Lance C.W.
AU - Darby, Alistair C.
AU - Davidson, Andrew D.
AU - Carroll, Miles W.
AU - Hiscox, Julian A.
PY - 2023
DA - March
TI - The P323L substitution in the SARS-CoV-2 polymerase (NSP12) confers a selective advantage during infection
JO - Genome Biology
VL - 24
DO - https://doi.org/10.1186/s13059-023-02881-5
AB - BACKGROUND: The mutational landscape of SARS-CoV-2 varies at the dominant viral genome sequence and minor genomic variant population. During the COVID-19 pandemic, an early substitution in the genome was the D614G change in the spike protein, associated with an increase in transmissibility. Genomes with D614G are accompanied by a P323L substitution in the viral polymerase (NSP12). However, P323L is not thought to be under strong selective pressure.
PB - Springer Nature
UR - https://www.research.ed.ac.uk/en/publications/2465619a-ad3d-4fa2-9ae4-280ced68428e
KW - Coronavirus (COVID-19)
ER