TY - JOUR
AU - Gualano, Bruno
AU - Sieczkowska, Sofia M.
AU - Pieres da Silva, Rafael
AU - Pinto, Ana J.
AU - Mazzolani, Bruna Caruso
AU - Smaira, Fabiana I.
AU - Aikawa, Nádia Emi
AU - Kupa, Leonard V.K.
AU - Pasoto, Sandra G.
AU - Medeiros-Ribeiro, Ana C.
AU - Saad, Carla G.S.
AU - Yuk, Emily F.N.
AU - Silva, Clovis A.
AU - Swinton, Paul
AU - Hallal, Pedro C.
AU - Roschel, Hamilton
AU - Lemes, Ítalo Ribeiro
AU - Bonfa, Eloisa
PY - 2023
DA - March
TI - Physical activity: a strategy to improve antibody response to a SARS-CoV-2 vaccine booster dose in patients with autoimmune rheumatic diseases
JO - Journal of Physical Activity and Health
EP - 316
VL - 20
IS - 4
DO - https://doi.org/10.1123/jpah.2022-0332
AB - Physical activity associates with improved immunogenicity following a 2-dose schedule of CoronaVac (Sinovac's inactivated SARS-CoV-2 vaccine) in patients with autoimmune rheumatic diseases (ARD). This study evaluates whether physical activity impacts vaccine-induced antibody responses to a booster dose in this population. This was a phase-4 trial conducted in Sao Paulo, Brazil. Patients with ARD underwent a 3-dose schedule of CoronaVac. One month after the booster, we assessed seroconversion rates of anti-SARS-CoV-2 S1/S2 IgG, geometric mean titers of anti-S1/S2 IgG, frequency of positive neutralizing antibodies, and neutralizing activity. Physical activity was assessed through questionnaire. Physically active (n = 362) and inactive (n = 278) patients were comparable for most characteristics; however, physically active patients were younger (P&lt;.01) and had a lower frequency of chronic inflammatory arthritis (P&lt;.01). Adjusted models showed that physically active patients had -2 times odds of seroconversion rates (OR: 2.09; 95% confidence interval, 1.22 to 3.61), -22% greater geometric mean titers of anti-S1/S2 IgG (22.09%; 95% confidence interval, 3.91 to 65.60), and -7% greater neutralizing activity (6.76%; 95% confidence interval, 2.80 to 10.72) than inactive patients. Patients with ARD who are physically active have greater odds of experiencing better immunogenicity to a booster dose of CoronaVac. These results support the recommendation of physical activity to improve vaccination responses, particularly for immunocompromised individuals.
PB - Human Kinetics
UR - https://rgu-repository.worktribe.com/output/1905895
KW - Coronavirus (COVID-19)
KW - Diet, healthy weight and physical activity
ER