TY - JOUR
AU - The COVID-19 Host Genetics Initiative
PY - 2022
DA - August
TI - A first update on mapping the human genetic architecture of COVID-19
JO - Nature
EP - E10
VL - 608
DO - https://doi.org/10.1038/s41586-022-04826-7
AB - The COVID-19 pandemic continues to pose a major public health threat, especially in countries with low vaccination rates. To better understand the biological underpinnings of SARS-CoV-2 infection and COVID-19 severity, we formed the COVID-19 Host Genetics Initiative. Here we present a genome-wide association study meta-analysis of up to 125,584 cases and over 2.5 million control individuals across 60 studies from 25 countries, adding 11 genome-wide significant loci compared with those previously identified. Genes at new loci, includingSFTPD,MUC5BandACE2, reveal compelling insights regarding disease susceptibility and severity.
PB - Springer Nature
UR - https://www.research.ed.ac.uk/en/publications/035ea0f3-fe8f-4af1-8b45-efb1c1b1b83d
KW - Coronavirus (COVID-19)
ER