TY - JOUR
AU - Fraser, Rupsha
AU - Orta-Resendiz, Aurelio
AU - Dockrell, David H.
AU - Müller-Trutwin, Michaela
AU - Mazein, Alexander
PY - 2023
DA - March
TI - Severe COVID-19 versus multisystem inflammatory syndrome: comparing two critical outcomes of SARS-CoV-2 infection
JO - European Respiratory Review
VL - 32
IS - 167
DO - https://doi.org/10.1183/16000617.0197-2022
AB - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with diverse host response immunodynamics and variable inflammatory manifestations. Several immune-modulating risk factors can contribute to a more severe coronavirus disease 2019 (COVID-19) course with increased morbidity and mortality. The comparatively rare post-infectious multisystem inflammatory syndrome (MIS) can develop in formerly healthy individuals, with accelerated progression to life-threatening illness. A common trajectory of immune dysregulation forms a continuum of the COVID-19 spectrum and MIS; however, severity of COVID-19 or the development of MIS is dependent on distinct aetiological factors that produce variable host inflammatory responses to infection with different spatiotemporal manifestations, a comprehensive understanding of which is necessary to set better targeted therapeutic and preventative strategies for both.
PB - European Respiratory Society
UR - https://www.research.ed.ac.uk/en/publications/85aea48f-faf3-4f37-b8f8-eea1938190b4
KW - Coronavirus (COVID-19)
ER