TY - JOUR
AU - Tamura, Tomokazu
AU - Ito, Jumpei
AU - Uriu, Keiya
AU - Zahradnik, Jiri
AU - Kida, Izumi
AU - Anraku, Yuki
AU - Nasser, Hesham
AU - Shofa, Maya
AU - Oda, Yoshitaka
AU - Lytras, Spyros
AU - Nao, Naganori
AU - Itakura, Yukari
AU - Deguchi, Sayaka
AU - Suzuki, Rigel
AU - Wang, Lei
AU - Kita, Shunsuke
AU - Yajima, Hisano
AU - Sasaki, Jiei
AU - Sasaki-Tabata, Kaori
AU - Shimizu, Ryo
AU - Tsuda, Masumi
AU - Kosugi, Yusuke
AU - Fujita, Shigeru
AU - Pan, Lin
AU - Sauter, Daniel
AU - Yoshimatsu, Kumiko
AU - Suzuki, Saori
AU - Asakura, Hiroyuki
AU - Nagashima, Mami
AU - Sadamasu, Kenji
AU - Yoshimura, Kazuhisa
AU - Yamamoto, Yuki
AU - Nagamoto, Tetsuharu
AU - Schreiber, Gideon
AU - Maenaka, Katsumi
AU - Hashiguchi, Takao
AU - Ikeda, Terumasa
AU - Fukuhara, Takasuke
AU - Saito, Akatsuki
AU - Tanaka, Shinya
AU - Matsuno, Keita
AU - Takayama, Kazuo
AU - Sato, Kei
AU - Begum, Mst Monira
PY - 2023
DA - May
TI - Virological characteristics of the SARS-CoV-2 XBB variant derived from recombination of two Omicron subvariants
JO - Nature Communications
VL - 14
DO - https://doi.org/10.1038/s41467-023-38435-3
AB - In late 2022, SARS-CoV-2 Omicron subvariants have become highly diversified, and XBB is spreading rapidly around the world. Our phylogenetic analyses suggested that XBB emerged through the recombination of two cocirculating BA.2 lineages, BJ.1 and BM.1.1.1 (a progeny of BA.2.75), during the summer of 2022. XBB.1 is the variant most profoundly resistant to BA.2/5 breakthrough infection sera to date and is more fusogenic than BA.2.75. The recombination breakpoint is located in the receptor-binding domain of spike, and each region of the recombinant spike confers immune evasion and increases fusogenicity. We further provide the structural basis for the interaction between XBB.1 spike and human ACE2. Finally, the intrinsic pathogenicity of XBB.1 in male hamsters is comparable to or even lower than that of BA.2.75. Our multiscale investigation provides evidence suggesting that XBB is the first observed SARS-CoV-2 variant to increase its fitness through recombination rather than substitutions.
PB - Springer Nature
UR - https://eprints.gla.ac.uk/298574/
KW - Coronavirus (COVID-19)
ER