TY - JOUR
AU - Liu, Alexander
AU - Hammond, Robert
AU - Chan, Kenneth
AU - Chukwuenweniwe, Chukwugozie
AU - Johnson, Rebecca
AU - Khair, Duaa
AU - Duck, Eleanor
AU - Olubodun, Oluwaseun
AU - Barwick, Kristian
AU - Banya, Winston
AU - Stirrup, James
AU - Donnelly, Peter D.
AU - Kaski, Juan Carlos
AU - Coates, Anthony R.M.
PY - 2023
DA - May
TI - Comparison of Lymphocyte-CRP ratio to conventional inflammatory markers for predicting clinical outcomes in COVID-19
JO - Journal of Personalized Medicine
VL - 13
IS - 6
DO - https://doi.org/10.3390/jpm13060909
AB - Background : In COVID-19 patients, lymphocyte–CRP ratio (LCR) is a promising biomarker for predicting adverse clinical outcomes. How well LCR performs compared to conventional inflammatory markers for prognosticating COVID-19 patients remains unclear, which hinders the clinical translation of this novel biomarker. Methods : In a cohort of COVID-19 inpatients, we characterised the clinical applicability of LCR by comparing its prognostic value against conventional inflammatory markers for predicting inpatient mortality and a composite of mortality, invasive/non-invasive ventilation and intensive care unit admissions. Results : Of the 413 COVID-19 patients, 100 (24%) patients suffered inpatient mortality. On Receiver Operating Characteristics analysis, LCR performed similarly to CRP for predicting mortality (AUC 0.74 vs. 0.71, p = 0.049) and the composite endpoint (AUC 0.76 vs. 0.76, p = 0.812). LCR outperformed lymphocyte counts (AUC 0.74 vs. 0.66, p = 0.002), platelet counts (AUC 0.74 vs. 0.61, p = 0.003) and white cell counts (AUC 0.74 vs. 0.54, p &lt; 0.001) for predicting mortality. On Kaplan–Meier analysis, patients with a low LCR (below a 58 cut-off) had worse inpatient survival than patients with other LCR values (p &lt; 0.001). Conclusion : LCR appears comparable to CRP, but outperformed other inflammatory markers, for prognosticating COVID-19 patients. Further studies are required to improve the diagnostic value of LCR to facilitate clinical translation.
PB - MDPI
UR - http://hdl.handle.net/10023/27695
KW - Coronavirus (COVID-19)
KW - Hospital care
ER