TY - JOUR
AU - Wilkinson, S.A.J.
AU - Richter, Alex
AU - Casey, Anna
AU - Osman, Husam
AU - Mirza, Jeremy
AU - Stockton, Joanne
AU - Quick, Joshua
AU - Ratcliffe, Liz
AU - Sparks, Natalie
AU - Cumley, Nicola
AU - Poplawski, Radoslaw
AU - Nicholls, Samuel M.
AU - Kele, Beatrix
AU - Harris, Kathryn
AU - COVID-19 Genomics UK (COG-UK) consortium
AU - Peacock, Thomas P.
AU - Loman, Nicholas J.
PY - 2022
DA - August
TI - Recurrent SARS-CoV-2 mutations in immunodeficient patients
JO - Virus Evolution
VL - 8
IS - 2
DO - https://doi.org/10.1093/ve/veac050
AB - Long-term severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections in immunodeficient patients are an important source of variation for the virus but are understudied. Many case studies have been published which describe one or a small number of long-term infected individuals but no study has combined these sequences into a cohesive dataset. This work aims to rectify this and study the genomics of this patient group through a combination of literature searches as well as identifying new case series directly from the COVID-19 Genomics UK (COG-UK) dataset. The spike gene receptor-binding domain and N-terminal domain (NTD) were identified as mutation hotspots. Numerous mutations associated with variants of concern were observed to emerge recurrently. Additionally a mutation in the envelope gene, T30I was determined to be the second most frequent recurrently occurring mutation arising in persistent infections. A high proportion of recurrent mutations in immunodeficient individuals are associated with ACE2 affinity, immune escape, or viral packaging optimisation.
PB - Oxford University Press
UR - https://publichealthscotland.scot/id/138732
KW - Coronavirus (COVID-19)
ER