TY - JOUR
AU - Thakur, Abhimanyu
AU - Liang, Lifan
AU - Banerjee, Sourav
AU - Zhang, Kui
PY - 2023
DA - May
TI - Single-Cell Transcriptomics Reveals Evidence of Endothelial Dysfunction in the Brains of COVID-19 Patients with Implications for Glioblastoma Progression
JO - Brain Sciences
VL - 13
IS - 5
DO - https://doi.org/10.3390/brainsci13050762
AB - Background: Endothelial dysfunction is implicated in various inflammatory diseases such as ischemic stroke, heart attack, organ failure, and COVID-19. Recent studies have shown that endothelial dysfunction in the brain is attributed to excessive inflammatory responses caused by the SARS-CoV-2 infection, leading to increased permeability of the blood-brain barrier and consequently neurological damage. Here, we aim to examine the single-cell transcriptomic landscape of endothelial dysfunction in COVID-19 and its implications for glioblastoma (GBM) progression.
PB - MDPI
UR - https://discovery.dundee.ac.uk/en/publications/36356da9-1678-48d6-9472-f1d5ddc38a56
KW - Coronavirus (COVID-19)
ER