TY - JOUR
AU - Ravanan, Rommel
AU - O'Callaghan, Chris J.
AU - Mumford, Lisa
AU - Ushiro-Lumb, Ines
AU - Thorburn, Douglas
AU - Casey, John
AU - Friend, Peter J.
AU - Parameshwar, Jayan
AU - Currie, Ian
AU - Burnapp, Lisa
AU - Baker, Richard
AU - Dudley, Jan
AU - Oniscu, Gabriel C
AU - Berman, Marius
AU - Asher, John
AU - Harvey, Dan
AU - Manara, Alex
AU - Manas, Derek M
AU - Gardiner, Dale
AU - Forsythe, John
PY - 2020
DA - August
TI - SARS-CoV-2 infection and early mortality of wait-listed and solid organ transplant recipients in England: a national cohort study
JO - American Journal of Transplantation
EP - 3018
VL - 20
IS - 11
DO - https://doi.org/10.1111/ajt.16247
AB - Patients wait-listed for and recipients of solid organ transplants (SOT) are perceived to have a higher risk of contracting SARS-CoV-2 and death; however, definitive epidemiological evidence is lacking. In a comprehensive national cohort study enabled by linkage of the UK transplant registry and Public Health England and NHS Digital Tracing services we examined the incidence of laboratory confirmed SARS-CoV-2 infection and subsequent mortality in patients on the active waiting list for a deceased donor SOT and recipients with a functioning SOT as of 1st February 2020 with follow up to 20th May 20202. Univariate and multivariable techniques were used to compare differences between groups and to control for case-mix. 197 (3·8%) of the 5,184 wait-listed patients and 597 (1·3%) of the 46,789 SOT recipients tested positive for SARS-CoV-2. Mortality after testing positive for SARS-CoV-2 was 10·2% (20/197) for wait-listed patients and 25·8% (154/597) for SOT recipients. Increasing recipient age was the only variable independently associated with death after positive SARS-CoV-2 test. Of the 1004 transplants performed in 2020, 41 (4·1%) recipients have tested positive for SARS-CoV-2 with 8 (0·8%) deaths reported by 20th May. These data provide evidence to support decisions on the risks and benefits of SOT during the COVID-19 pandemic.
PB - Wiley
UR - https://www.research.ed.ac.uk/en/publications/fdda2ae1-292a-4795-9234-7a4aeda7a36b
KW - Coronavirus (COVID-19)
ER