TY - JOUR
AU - Barnes, Eleanor
AU - Goodyear, Carl S.
AU - Willicombe, Michelle
AU - Gaskell, Charlotte
AU - Siebert, Stefan
AU - de Silva, Thushan I.
AU - Murray, Sam M.
AU - Rea, Daniel
AU - Snowden, John A.
AU - Carroll, Miles W.
AU - Pirrie, Sarah
AU - Bowden, Sarah J.
AU - Dunachie, Susanna
AU - Richter, Alex
AU - Lim, Zixiang
AU - Satsangi, Jack
AU - Cook, Gordon
AU - Pope, Ann
AU - Hughes, Ana
AU - Harrison, Molly
AU - Lim, Sean H.
AU - Miller, Paul
AU - Klenerman, Paul
AU - Richter, Alex G.
AU - Mentzer, Alexander J.
AU - Deeks, Alexandra
AU - Jamsen, Anni
AU - Brown, Anthony
AU - Conlon, Chris
AU - Dold, Christina
AU - Duncan, Christopher J.A.
AU - Skelly, Donal
AU - Kronsteiner, Barbara
AU - Abraham, Priyanka
AU - Phillips, Eloise
AU - Jeffery, Katie
AU - Turtle, Lance C.W.
AU - Frending, Lisa
AU - Stafford, Lizzie
AU - Ali, Mohammad
AU - Rongkard, Patpong
AU - Payne, Rebecca P.
AU - Adele, Sandra
AU - Travis, Simon
AU - Gardiner, Siobhan
AU - Dobson, Susan
AU - Malone, Tom
AU - Bibi, Sagida
AU - Carroll, Miles W.
AU - Faustini, Sian
AU - Foulkes, Sarah
AU - Frater, John
AU - Hall, Victoria J.
AU - Hopkins, Susan
AU - Islam, Jasmin
AU - Lambe, Teresa
AU - Longet, Stephanie
AU - Moore, Shona C.
AU - Otter, Ashley David
AU - Rowland-Jones, Sarah L.
AU - Thaventhir, James E. D.
AU - Wootton, Daniel G.
AU - Basu, Neil
AU - Gilmour, Ashley
AU - Irwin, Sophie
AU - Meacham, Georgina
AU - Marjot, Thomas
AU - Dimitriadis, Stavros
AU - Kelleher, Peter
AU - Prendecki, Maria
AU - Clarke, Candice L.
AU - Mortimer, Paige
AU - McIntyre, Stacey
AU - Selby, Rachael
AU - Meardon, Naomi
AU - Nguyen, Dung
AU - Tipton, Tom
AU - Longet, Stephanie
AU - Laidlaw, Stephen
AU - Orchard, Kim
AU - Ireland, Georgina
AU - Brown, Kevin E.
AU - Amirthalingam, Gayatri
AU - Thomas, David
AU - Kearns, Pamela
AU - Kirkham, Amanda
AU - McInnes, Iain B.
AU - Beesley, Richard
AU - Churchill, Vicky
AU - Loughton, Holly
AU - Insch, Elspeth
AU - MacDonald, Eilean
AU - Middleton, Gary
AU - Billingham, Lucinda
AU - Lowe, Faye
AU - Magwaro, Sophia
AU - Al-Taei, Saly
AU - Arnott, Maxine
AU - Bennett, Louise
AU - Brock, James
AU - Keillor, Victora
AU - Melville, Andrew
AU - Melville, Lisa
AU - Miller, Samantha
AU - Najm, Aurelie
AU - Paterson, Caron
AU - Rodgers, Lewis
AU - Rutherford, Matthew A.
AU - Rundell, Suzann
AU - Smith, Emily R
AU - Stewart, Lynn
AU - Sunzini, Flavia
AU - Tong, Andrew
AU - Woolcock, Kieran
AU - Basheer, Faisal
AU - Crawley, Charles
AU - Malladi, Ram
AU - King, Andrew M.Q.
AU - Lockey, Sophie
AU - Uttenthal, Ben
AU - Koh, Mickey B. C.
AU - Hansford, Samantha E.
AU - Sandhar, Gurjinder
AU - Kesavan, Murali
AU - Moore, Celia
AU - Manousou, Pinelopi
AU - Hahn, Gareth
AU - Mullish, Benjamin
AU - Atta, Maria
AU - Gleeson, Sarah
AU - Lightstone, Liz
AU - Martin, Paul
AU - McAdoo, Stephen P.
AU - Thomson, Tina
AU - Avenoso, Daniele
AU - Sanderson, Robin
AU - Taylor, Claire
AU - Bhandal, Khushpreet
AU - Hull, Diana
AU - Trivedi, Palak
AU - Filer, Andrew
AU - Hurst, Erin
AU - Publicover, Amy
AU - Scouse, Katy
AU - Chalk, Jem
AU - Hanke, Daniel
AU - Hanke, Josef
AU - Healy, Saoirse
AU - Provine, Nicholas
AU - Thomas, Sarah
AU - Walker, Victoria
AU - Win, Zay
AU - Trown, Doreen
AU - Faria, Patricia
AU - Chackathayil, Julia
AU - Hutchison, Clare
AU - Richardson, Deborah
PY - 2023
DA - July
TI - SARS-CoV-2-specific immune responses and clinical outcomes after COVID-19 vaccination in patients with immune-suppressive disease
JO - Nature Medicine
DO - https://doi.org/10.1038/s41591-023-02414-4
AB - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immune responses and infection outcomes were evaluated in 2,686 patients with varying immune-suppressive disease states after administration of two Coronavirus Disease 2019 (COVID-19) vaccines. Overall, 255 of 2,204 (12%) patients failed to develop anti-spike antibodies, with an additional 600 of 2,204 (27%) patients generating low levels (&lt;380 AU ml−1). Vaccine failure rates were highest in ANCA-associated vasculitis on rituximab (21/29, 72%), hemodialysis on immunosuppressive therapy (6/30, 20%) and solid organ transplant recipients (20/81, 25% and 141/458, 31%). SARS-CoV-2-specific T cell responses were detected in 513 of 580 (88%) patients, with lower T cell magnitude or proportion in hemodialysis, allogeneic hematopoietic stem cell transplantation and liver transplant recipients (versus healthy controls). Humoral responses against Omicron (BA.1) were reduced, although cross-reactive T cell responses were sustained in all participants for whom these data were available. BNT162b2 was associated with higher antibody but lower cellular responses compared to ChAdOx1 nCoV-19 vaccination. We report 474 SARS-CoV-2 infection episodes, including 48 individuals with hospitalization or death from COVID-19. Decreased magnitude of both the serological and the T cell response was associated with severe COVID-19. Overall, we identified clinical phenotypes that may benefit from targeted COVID-19 therapeutic strategies.
PB - Springer Nature
UR - https://eprints.gla.ac.uk/302522/
KW - Coronavirus (COVID-19)
ER