TY - JOUR
AU - de Silva, Thushan I.
AU - Liu, Guihai
AU - Lindsey, Benjamin B.
AU - Dong, Danning
AU - Moore, Shona C.
AU - Hsu, Sharon N.
AU - Shah, Dhruv R.
AU - Wellington, Dannielle
AU - Mentzer, Alexander J.
AU - Angyal, Adrienn
AU - Brown, Rebecca
AU - Parker, Matthew D.
AU - Ying, Zixi
AU - Yao, Xuan
AU - Turtle, Lance C. W.
AU - Dunachie, Susanna
AU - Maini, Mala K.
AU - Ogg, Graham
AU - Knight, Julian C.
AU - Peng, Yanchun
AU - Rowland-Jones, Sarah L.
AU - Dong, Tao
AU - COVID-19 Genomics UK (COG-UK) consortium
AU - ISARIC4C Investigators
PY - 2021
DA - November
TI - The impact of viral mutations on recognition by SARS-CoV-2 specific T cells
JO - iScience
VL - 24
IS - 11
DO - https://doi.org/10.1016/j.isci.2021.103353
AB - We identify amino acid variants within dominant SARS-CoV-2 T cell epitopes by interrogating global sequence data. Several variants within nucleocapsid and ORF3a epitopes have arisen independently in multiple lineages and result in loss of recognition by epitope-specific T cells assessed by IFN-γ and cytotoxic killing assays. Complete loss of T cell responsiveness was seen due to Q213K in the A∗01:01-restricted CD8+ ORF3a epitope FTSDYYQLY207-215; due to P13L, P13S, and P13T in the B∗27:05-restricted CD8+ nucleocapsid epitope QRNAPRITF9-17; and due to T362I and P365S in the A∗03:01/A∗11:01-restricted CD8+ nucleocapsid epitope KTFPPTEPK361-369. CD8+ T cell lines unable to recognize variant epitopes have diverse T cell receptor repertoires. These data demonstrate the potential for T cell evasion and highlight the need for ongoing surveillance for variants capable of escaping T cell as well as humoral immunity.
PB - Elsevier
UR - https://www.research.ed.ac.uk/en/publications/4eb7c977-7bc4-4bcb-a698-c3e84ae431c4
KW - Coronavirus (COVID-19)
ER