TY - JOUR
AU - George, Molly S.
AU - Sanchez, Jenifer
AU - Rollings, Christina
AU - Fear, David J.
AU - Irving, Peter M
AU - Sinclair, Linda V.
AU - Schurich, Anna
PY - 2023
DA - July
TI - Extracellular vesicles in COVID-19 convalescence can regulate T cell metabolism and function
JO - iScience
VL - 26
IS - 8
DO - https://doi.org/10.1016/j.isci.2023.107280
AB - Long-term T cell dysregulation has been reported following COVID-19 disease. Prolonged T cell activation is associated with disease severity and may be implicated in producing long-covid symptoms. Here, we assess the role of extracellular vesicles (EV) in regulating T cell function over several weeks post COVID-19 disease. We find that alterations in cellular origin and protein content of EV in COVID-19 convalescence are linked to initial disease severity. We demonstrate that convalescent donor-derived EV can alter the function and metabolic rewiring of CD4 and CD8 T cells. Of note, EV following mild, but not severe disease, show distinctly immune-suppressive properties, reducing T cell effector cytokine production and glucose metabolism. Mechanistically our data indicate the involvement of EV-surface ICAM-1 in facilitating EV—T cell interaction. Our data demonstrate that circulatory EV are phenotypically and functionally altered several weeks following acute infection, suggesting a role for EV as long-term immune modulators.
PB - Elsevier
UR - https://discovery.dundee.ac.uk/en/publications/6e5cf4f3-4620-496f-a27b-4e26c2254f6f
KW - Coronavirus (COVID-19)
ER