TY - JOUR
AU - Smaira, Fabiana Infante
AU - Mazzolani, Bruna Caruso
AU - Lemes, Ítalo Ribeiro
AU - Pires da Silva, Rafael
AU - Pinto, Ana J.
AU - Sieczkowska, Sofia M.
AU - Aikawa, Nádia Emi
AU - Pasoto, Sandra G.
AU - Medeiros-Ribeiro, Ana C.
AU - Saad, Carla G.S.
AU - Yuk, Emily F.N.
AU - Silva, Clovis A.
AU - Swinton, Paul
AU - Kupa, Leonard V.K.
AU - Hallal, Pedro C.
AU - Roschel, Hamilton
AU - Gualano, Bruno
AU - Bonfa, Eloisa
PY - 2023
DA - June
TI - No associations between physical activity and immunogenicity in SARS-CoV-2 seropositive patients with autoimmune rheumatic diseases prior to and after vaccination.
JO - Journal of Physical Activity and Health
DO - https://doi.org/10.1123/jpah.2022-0362
AB - To investigate the association between physical activity and immunogenicity among SARS-CoV-2 seropositive patients with autoimmune rheumatic diseases prior to and following a 2-dose schedule of CoronaVac (Sinovac inactivated vaccine). This was a prospective cohort study within an open-label, single-arm, phase 4 vaccination trial conducted in Sao Paulo, Brazil. In this substudy, only SARS-CoV-2 seropositive patients were included. Immunogenicity was assessed by seroconversion rates of total anti-SARS-CoV-2 S1/S2 immunoglobulin G (IgG), geometric mean titers of anti-S1/S2 IgG, frequency of positive neutralizing antibodies, and neutralizing activity before and after vaccination. Physical activity was assessed through a questionnaire. Model-based analyses were performed controlling for age (&lt;60 or ≥60 y), sex, body mass index (&lt;25, 25–30, and &gt;30 kg/m2), and use of prednisone, immunosuppressants, and biologics. A total of 180 seropositive autoimmune rheumatic disease patients were included. There was no association between physical activity and immunogenicity before and after vaccination. This study suggests that the positive association between physical activity and greater antibody responses seen in immunocompromised individuals following vaccination is overridden by previous SARS-CoV-2 infection, and does not extend to natural immunity.
PB - Human Kinetics
UR - https://rgu-repository.worktribe.com/output/1982547
KW - Coronavirus (COVID-19)
KW - Diet, healthy weight and physical activity
ER