TY - JOUR
AU - Baillie, J. Kenneth
AU - Yang, Hongbing
AU - Sun, Hong
AU - Brackenridge, Simon
AU - Zhuang, Xiaodong
AU - Wing, Peter A.C.
AU - Quastel, Max
AU - Walters, Lucy
AU - Garner, Lee
AU - Wang, Beibei
AU - Yao, Xuan
AU - Felce, Suet Ling
AU - Peng, Yanchun
AU - Moore, Shona C.
AU - Peeters, Bas W.A.
AU - Rei, Margarida
AU - Gomes, João Paulo
AU - Tomas, Ana Luisa
AU - Davidson, Andrew D.
AU - Semple, Malcolm G.
AU - Turtle, Lance C.W.
AU - Openshaw, Peter J.M.
AU - Mentzer, Alexander J.
AU - Klenerman, Paul
AU - ISARIC4C Investigators
AU - Borrow, Persephone
AU - Dong, Tao
AU - McKeating, Jane A.
AU - Gillespie, Geraldine M.
AU - McMichael, Andrew J.
PY - 2023
DA - June
TI - HLA-E-restricted SARS-CoV-2-specific T cells from convalescent COVID-19 patients suppress virus replication despite HLA class Ia down-regulation
JO - Science Immunology
VL - 8
IS - 84
DO - https://doi.org/10.1126/sciimmunol.abl8881
AB - Pathogen-specific CD8+ T cell responses restricted by the nonpolymorphic nonclassical class Ib molecule human leukocyte antigen E (HLA-E) are rarely reported in viral infections. The natural HLA-E ligand is a signal peptide derived from classical class Ia HLA molecules that interact with the NKG2/CD94 receptors to regulate natural killer cell functions, but pathogen-derived peptides can also be presented by HLA-E. Here, we describe five peptides from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that elicited HLA-E-restricted CD8+ T cell responses in convalescent patients with coronavirus disease 2019. These T cell responses were identified in the blood at frequencies similar to those reported for classical HLA-Ia-restricted anti-SARS-CoV-2 CD8+ T cells. HLA-E peptide-specific CD8+ T cell clones, which expressed diverse T cell receptors, suppressed SARS-CoV-2 replication in Calu-3 human lung epithelial cells. SARS-CoV-2 infection markedly down-regulated classical HLA class I expression in Calu-3 cells and primary reconstituted human airway epithelial cells, whereas HLA-E expression was not affected, enabling T cell recognition. Thus, HLA-E-restricted T cells could contribute to the control of SARS-CoV-2 infection alongside classical T cells.
PB - American Association for the Advancement of Science
UR - https://www.research.ed.ac.uk/en/publications/dd33eee5-762b-4661-9e9d-62690dd2090f
KW - Coronavirus (COVID-19)
ER