TY - JOUR
AU - Volz, Erik
AU - Hill, Verity
AU - McCrone, John T.
AU - Price, Anna
AU - Jorgensen, David
AU - O'Toole, Áine Niamh
AU - Southgate, Joel
AU - Johnson, Robert
AU - Jackson, Ben
AU - Nascimento, Fabricia F.
AU - Rey, Sara M.
AU - Nicholls, Samuel M.
AU - Colquhoun, Rachel M.
AU - da Silva Filipe, Ana
AU - Shepherd, James
AU - Pascall, David
AU - Shah, Rajiv
AU - Jesudason, Natasha
AU - Li, Kathy K.
AU - Jarrett, Ruth F.
AU - Pacchiarini, Nicole
AU - Bull, Matthew
AU - Geidelberg, Lily
AU - Siveroni, Igor
AU - Goodfellow, Ian G.
AU - Loman, Nicholas J.
AU - Pybus, Oliver G.
AU - Robertson, David L.
AU - Thomson, Emma C.
AU - Rambaut, Andrew
AU - Connor, Thomas R.
PY - 2020
DA - November
TI - Evaluating the effects of SARS-CoV-2 Spike mutation D614G on transmissibility and pathogenicity
JO - Cell
EP - 75
VL - 184
IS - 1
DO - http://dx.doi.org/10.1016/j.cell.2020.11.020
AB - Global dispersal and increasing frequency of the SARS-CoV-2 Spike protein variant D614G are suggestive of a selective advantage but may also be due to a random founder effect. We investigate the hypothesis for positive selection of Spike D614G in the United Kingdom using more than 25,000 whole genome SARS-CoV-2 sequences. Despite the availability of a large data set, well represented by both Spike 614 variants, not all approaches showed a conclusive signal of positive selection. Population genetic analysis indicates that 614G increases in frequency relative to 614D in a manner consistent with a selective advantage. We do not find any indication that patients infected with the Spike 614G variant have higher COVID-19 mortality or clinical severity, but 614G is associated with higher viral load and younger age of patients. Significant differences in growth and size of 614G phylogenetic clusters indicate a need for continued study of this variant.
PB - Elsevier
UR - http://eprints.gla.ac.uk/225771/
KW - Coronavirus (COVID-19)
ER