TY - JOUR
AU - Steinberg, Julia
AU - Hughes, Suzanne
AU - Hui, Harriet
AU - Allsop, Matthew J
AU - Egger, Sam
AU - David, Michael Z.
AU - Caruana, Michael
AU - Coxeter, Peter
AU - Carle, Chelsea
AU - Onyeka, Tonia
AU - Rewais, Isabel
AU - Monroy Iglesias, Maria J
AU - Vives, Nuria
AU - Wei, Feixue
AU - Abila, Derrick Bary
AU - Carreras, Giulia
AU - Santero, Marilina
AU - O'Dowd, Emma L
AU - Lui, Gigi
AU - Tolani, Musliu Adetola
AU - Mullooly, Maeve
AU - Lee, Shing Fung
AU - Landy, Rebecca
AU - Hanley, Sharon J.B.
AU - Binefa, Gemma
AU - McShane, Charlene M.
AU - Gizaw, Muluken
AU - Selvamuthu, Poongulali
AU - Boukheris, Houda
AU - Nakaganda, Annet
AU - Ergin, Isil
AU - Moraes, Fabio Ynoe
AU - Timilshina, Nahari
AU - Kumar, Ashutosh
AU - Vale, Diama B
AU - Molina-Barceló, Ana
AU - Force, Lisa M
AU - Campbell, Denise Joan
AU - Wang, Yuqing
AU - Wan, Fang
AU - Baker, Anna-Lisa
AU - Singh, Ramnik
AU - Salam, Rehana Abdus
AU - Yuill, Susan
AU - Shah, Richa
AU - Lansdorp-Vogelaar, Iris
AU - Yusuf, Aasim
AU - Aggarwal, Ajay
AU - Murillo, Raul
AU - Torode, Julie S
AU - Kliewer, Erich V
AU - Bray, Freddie
AU - Chan, Kelvin K W
AU - Peacock, Stuart
AU - Hanna, Timothy P
AU - Ginsburg, Ophira
AU - Van Hemelrijck, Mieke
AU - Sullivan, Richard
AU - Roitberg, Felipe
AU - Ilbawi, André M
AU - Soerjomataram, Isabelle
AU - Canfell, Karen
PY - 2023
DA - December
TI - Risk of COVID-19 death for people with a pre-existing cancer diagnosis prior to COVID-19-vaccination: A systematic review and meta-analysis
JO - International Journal of Cancer
DO - https://doi.org/10.1002/ijc.34798
AB - While previous reviews found a positive association between pre-existing cancer diagnosis and COVID-19-related death, most early studies did not distinguish long-term cancer survivors from those recently diagnosed/treated, nor adjust for important confounders including age. We aimed to consolidate higher-quality evidence on risk of COVID-19-related death for people with recent/active cancer (compared to people without) in the pre-COVID-19-vaccination period. We searched the WHO COVID-19 Global Research Database (20 December 2021), and Medline and Embase (10 May 2023). We included studies adjusting for age and sex, and providing details of cancer status. Risk-of-bias assessment was based on the Newcastle-Ottawa Scale. Pooled adjusted odds or risk ratios (aORs, aRRs) or hazard ratios (aHRs) and 95% confidence intervals (95% CIs) were calculated using generic inverse-variance random-effects models. Random-effects meta-regressions were used to assess associations between effect estimates and time since cancer diagnosis/treatment. Of 23 773 unique title/abstract records, 39 studies were eligible for inclusion (2 low, 17 moderate, 20 high risk of bias). Risk of COVID-19-related death was higher for people with active or recently diagnosed/treated cancer (general population: aOR = 1.48, 95% CI: 1.36-1.61,I2= 0; people with COVID-19: aOR = 1.58, 95% CI: 1.41-1.77,I2= 0.58; inpatients with COVID-19: aOR = 1.66, 95% CI: 1.34-2.06,I2= 0.98). Risks were more elevated for lung (general population: aOR = 3.4, 95% CI: 2.4-4.7) and hematological cancers (general population: aOR = 2.13, 95% CI: 1.68-2.68,I2= 0.43), and for metastatic cancers. Meta-regression suggested risk of COVID-19-related death decreased with time since diagnosis/treatment, for example, for any/solid cancers, fitted aOR = 1.55 (95% CI: 1.37-1.75) at 1 year and aOR = 0.98 (95% CI: 0.80-1.20) at 5 years post-cancer diagnosis/treatment. In conclusion, before COVID-19-vaccination, risk of COVID-19-related death was higher for people with recent cancer, with risk depending on cancer type and time since diagnosis/treatment.
PB - Wiley
UR - https://hdl.handle.net/2164/22414
KW - Coronavirus (COVID-19)
ER