TY - JOUR
AU - Williams, Thomas C
AU - Marlow, Robin
AU - Hardelid, Pia
AU - Lyttle, Mark d
AU - Lewis, Kate m
AU - Mpamhanga, Chengetai d
AU - Cunningham, Steve
AU - Roland, Damian
AU - Fraser, Karena
AU - Baker, James
AU - Bailie, Helen
AU - Tolhurst-Cleaver, Meriel
AU - Stellman, Rob
AU - Hartshorn, Stuart
AU - Watson, Jessica
AU - Begley, Roisin
AU - Hingley, Sakura
AU - Dutta, Manali
AU - Ramsden, Gemma
AU - Ryan, Eleanor
AU - Durnin, Sheena
AU - Koe, Stanley
AU - Halasz, Gergely
AU - Brearey, Steve
AU - Ranasinghe, Darren
AU - Gopi, Mudiyur
AU - Spalding, Claudia
AU - Gomes, Sylvester
AU - Woods, Gracita
AU - Aldridge, Patrick
AU - Owens, Vicky
AU - Balehithlu, Hemantha
AU - Richardson, Simon
AU - Hartin, David
AU - Mitchell, Rachael
AU - Downes, Alice
AU - Roland, Damian
AU - Sequeira, Sabrina
AU - Tillett, Jo
AU - Dowson, Simon
AU - Tomlinson, Jo
AU - Da costa, Adebayo
AU - Sime, Alfred
AU - Kirby, Claire
AU - Lawton, Adam
AU - Wear, Ruth
AU - Gough, Christopher
AU - Gardner, Sharryn
AU - Haslam, Zena
AU - Rimmer, Craig
AU - Steensma, Jiske
AU - Rao, Sahana
AU - Deall, Heather
AU - Hall, Sharon
AU - Middleton, Catriona
AU - Walton, Emily
AU - Mackenzie, Friyana dastur
AU - Thakker, Manish
AU - Robinson, Gisela
AU - Johnson, Graham
AU - Wong, Shye
AU - Diaba, Cynthia
AU - Foster, Steve
AU - Browning, Jen
AU - Rooney, Lynsey
AU - Challen, Kirsty
AU - Rosser, Michael
AU - Patel, Pratiksha
AU - Spicer, Amy
AU - Bagshaw, Lorna
AU - Gray, Seb
AU - Gibbs, Sally
AU - Mullen, Niall
AU - Fairley, Louise
AU - Bayreuther, Jane
AU - James, David
AU - Jarman, Heather
AU - O'leary, Clare
AU - Clerihew, Linda
AU - Astin-Chamberlain, Raine
AU - Trippick, Sarah
AU - Armstrong, Lawrence
AU - Mulligan, Joanne
AU - Keers, Sophie
AU - Cahill, Benjamin
AU - Mohammad, Misbah
AU - Burridge, Richard
AU - Wilson, Sarah
AU - Anpananthar, Amutha
AU - Jamall, Erum
AU - Lacy, David
PY - 2023
DA - December
TI - Clinical Impact of Serious Respiratory Disease in Children Under the Age of 2 Years During the 2021–2022 Bronchiolitis Season in England, Scotland, and Ireland
JO - Journal of Infectious Diseases
DO - https://doi.org/10.1093/infdis/jiad551
AB - Background Interventions introduced to reduce the spread of SARS-CoV-2 led to a widespread reduction in childhood infections. However, from spring 2021 onwards the United Kingdom and Ireland experienced an unusual out-of-season epidemic of respiratory disease. Methods We conducted a prospective observational study (BronchStart), enrolling children 0-23 months of age presenting with bronchiolitis, lower respiratory tract infection or first episode of wheeze to 59 Emergency Departments across England, Scotland and Ireland from May 2021 to April 2022. We combined testing data with national admissions datasets to infer the impact of respiratory syncytial virus (RSV) disease. Results The BronchStart study collected data on 17,899 presentations for 17,164 children. Risk factors for admission and escalation of care included prematurity and congenital heart disease, but most admissions were for previously healthy term-born children. Of those aged 0-11 months who were admitted and tested for RSV, 1,907/3,912 (48.7%) tested positive. We estimate that every year in England and Scotland 28,561 (95% confidence interval 27,637-29,486) infants are admitted with RSV infection. Conclusions RSV infection was the main cause of hospitalisations in this cohort, but 51.3% of admissions in infants were not associated with the virus. The majority of admissions were in previously healthy term-born infants.
PB - Oxford University Press
UR - https://www.research.ed.ac.uk/en/publications/3d5df24d-dedc-4c81-8879-1c2225e67c44
KW - Coronavirus (COVID-19)
KW - Children, young people and families
ER