TY - JOUR
AU - Michael, Benedict D.
AU - Dunai, Cordelia
AU - Needham, Edward J.
AU - Tharmaratnam, Kukatharmini
AU - Williams, Robyn
AU - Huang, Yun
AU - Boardman, Sarah A.
AU - Clark, Jordan
AU - Sharma, Parul
AU - Subramaniam, Krishanthi S
AU - Wood, Greta K.
AU - Collie, Ceryce
AU - Digby, Richard J.
AU - Ren, Alexander L.
AU - Norton, Emma J.
AU - Leibowitz, Maya M.
AU - Ebrahimi, Soraya
AU - Fowler, Andrew
AU - Fox, Hannah
AU - Tato, Esteban
AU - Ellul, Mark A.
AU - Sunderland, Geraint
AU - Held, Marie
AU - Hetherington, Claire
AU - Egbe, Franklyn N.
AU - Palmos, Alish B
AU - Stirrups, Kathy
AU - Grundmann, Alexander
AU - Chiollaz, Anne-Cecile
AU - Sanchez, Jean-Charles
AU - Stewart, James P.
AU - Griffiths, Michael J.
AU - Solomon, Tom
AU - Breen, Gerome
AU - Coles, Alasdair J.
AU - Kingston, Nathalie
AU - Bradley, John R.
AU - Chinnery, Patrick F.
AU - Cavanagh, Jonathan
AU - Irani, Sarosh R.
AU - Vincent, Angela
AU - Baillie, J. Kenneth
AU - Openshaw, Peter J.
AU - Semple, Malcolm G.
AU - Taams, Leonie S.
AU - Menon, David K.
PY - 2023
DA - December
TI - Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses
JO - Nature Communications
VL - 14
DO - https://doi.org/10.1038/s41467-023-42320-4
AB - To understand neurological complications of COVID-19 better both acutely and for recovery, we measured markers of brain injury, inflammatory mediators, and autoantibodies in 203 hospitalised participants; 111 with acute sera (1–11 days post-admission) and 92 convalescent sera (56 with COVID-19-associated neurological diagnoses). Here we show that compared to 60 uninfected controls, tTau, GFAP, NfL, and UCH-L1 are increased with COVID-19 infection at acute timepoints and NfL and GFAP are significantly higher in participants with neurological complications. Inflammatory mediators (IL-6, IL-12p40, HGF, M-CSF, CCL2, and IL-1RA) are associated with both altered consciousness and markers of brain injury. Autoantibodies are more common in COVID-19 than controls and some (including against MYL7, UCH-L1, and GRIN3B) are more frequent with altered consciousness. Additionally, convalescent participants with neurological complications show elevated GFAP and NfL, unrelated to attenuated systemic inflammatory mediators and to autoantibody responses. Overall, neurological complications of COVID-19 are associated with evidence of neuroglial injury in both acute and late disease and these correlate with dysregulated innate and adaptive immune responses acutely.
PB - Springer Nature
UR - https://eprints.gla.ac.uk/315366/
KW - Coronavirus (COVID-19)
KW - Hospital care
ER