TY - JOUR
AU - Alsahab, Mustafa
AU - Beishon, Lucy
AU - Brown, Bryony
AU - Burn, Elinor
AU - Burton, Jennifer Kirsty
AU - Cox, Natalie
AU - Dani, Melanie
AU - Elhadi, Muhammed
AU - Freshwater, Sarah
AU - Gaunt, Victoria
AU - Gordon, Adam L.
AU - Goujon, Marie
AU - Hale, Matthew
AU - Hughes, Terry
AU - Jackson, Thomas A.
AU - Jelley, Benjamin
AU - Khan, Asma
AU - Khiroya, Heena
AU - Lal, Rajni
AU - Madden, Katy
AU - Magill, Laura
AU - Masoli, Jane
AU - Masud, Tahir
AU - McCluskey, Lauren
AU - McNeela, Natalie
AU - Mohammedseid-Nurhussien, Awolkhier
AU - Moorey, Hannah
AU - Lochlainn, Mary Ni
AU - Nirantharakumar, Krishnarajah
AU - Okoth, Kelvin
AU - Osuafor, Christopher N.
AU - Patterson, Katherine
AU - Pearson, Grace M.E.
AU - Perry, Rita
AU - Pettitt, Michala
AU - Pigott, Jennifer
AU - Pinkney, Thomas
AU - Quinn, Terence J.
AU - Reynolds, Abigail
AU - Richardson, Sarah
AU - Sanyal, Nik
AU - Seed, Adam
AU - Sleeman, Isobel
AU - Soo, Chee
AU - Steves, Claire
AU - Strain, W. David
AU - Taylor, Joanne
AU - Torsney, Kelli
AU - Welch, Carly
AU - Wilson, Daisy
AU - Witham, Miles
PY - 2021
DA - February
TI - Age and frailty are independently associated with increased COVID-19 mortality and increased care needs in survivors: results of an international multi-centre study
JO - Age and Ageing
DO - http://dx.doi.org/10.1093/ageing/afab026
AB - Introduction: Increased mortality has been demonstrated in older adults with COVID-19, but the effect of frailty has been unclear. Methods: This multi-centre cohort study involved patients aged 18 years and older hospitalised with COVID-19, using routinely collected data. We used Cox regression analysis to assess the impact of age, frailty, and delirium on the risk of inpatient mortality, adjusting for sex, illness severity, inflammation, and co-morbidities. We used ordinal logistic regression analysis to assess the impact of age, Clinical Frailty Scale (CFS), and delirium on risk of increased care requirements on discharge, adjusting for the same variables. Results: Data from 5,711 patients from 55 hospitals in 12 countries were included (median age 74, IQR 54–83; 55.2% male). The risk of death increased independently with increasing age (&gt;80 vs 18–49: HR 3.57, CI 2.54–5.02), frailty (CFS 8 vs 1–3: HR 3.03, CI 2.29–4.00) inflammation, renal disease, cardiovascular disease, and cancer, but not delirium. Age, frailty (CFS 7 vs 1–3: OR 7.00, CI 5.27–9.32), delirium, dementia, and mental health diagnoses were all associated with increased risk of higher care needs on discharge. The likelihood of adverse outcomes increased across all grades of CFS from 4 to 9. Conclusions: Age and frailty are independently associated with adverse outcomes in COVID-19. Risk of increased care needs was also increased in survivors of COVID-19 with frailty or older age.
PB - Oxford University Press
UR - http://eprints.gla.ac.uk/233878/
KW - Coronavirus (COVID-19)
KW - Older people
ER