TY - JOUR
AU - Dee, Kieran
AU - Goldfarb, Daniel M.
AU - Haney, Joanne
AU - Amat, Julien A.R.
AU - Herder, Vanessa
AU - Stewart, Meredith
AU - Szemiel, Agnieszka M.
AU - Baguelin, Marc
AU - Murcia, Pablo R.
PY - 2021
DA - March
TI - Human rhinovirus infection blocks SARS-CoV-2 replication within the respiratory epithelium: implications for COVID-19 epidemiology
JO - Journal of Infectious Diseases
DO - https://doi.org/10.1093/infdis/jiab147
AB - Virus-virus interactions influence the epidemiology of respiratory infections. However, the impact of viruses causing upper respiratory infections on SARS-CoV-2 replication and transmission is currently unknown. Human rhinoviruses cause the common cold and are the most prevalent respiratory viruses of humans. Interactions between rhinoviruses and co-circulating respiratory viruses have been shown to shape virus epidemiology at the individual host and population level. Here, we examined the replication kinetics of SARS-CoV-2 in the human respiratory epithelium in the presence or absence of rhinovirus. We show that human rhinovirus triggers an interferon response that blocks SARS-CoV-2 replication. Mathematical simulations show that this virus-virus interaction is likely to have a population-wide effect as an increasing prevalence of rhinovirus will reduce the number of new COVID-19 cases.
PB - Oxford University Press
UR - http://eprints.gla.ac.uk/236452/
KW - Coronavirus (COVID-19)
ER