TY - JOUR
AU - Lu, Jing
AU - du Plessis, Louis
AU - Liu, Zhe
AU - Hill, Verity
AU - Kang, Min
AU - Lin, Huifang
AU - Sun, Jiufeng
AU - Francois, Sarah
AU - Kraemer, Moritz U.G.
AU - Faria, Nuno Rodrigues
AU - McCrone, John T.
AU - Peng, Jinju
AU - Xiong, Qianling
AU - Yuan, Runyu
AU - Zeng, Lilian
AU - Zhou, Pingping
AU - Liang, Chumin
AU - Yi, Lina
AU - Liu, Jun
AU - Xiao, Jianpeng
AU - Hu, Jianxiong
AU - Liu, Tao
AU - Ma, Wenjun
AU - Li, Wei
AU - Su, Juan
AU - Zheng, Huanying
AU - Peng, Bo
AU - Fang, Shisong
AU - Su, Wenzhe
AU - Kuibiao, Li
AU - Sun, Ruilin
AU - Bai, Ru
AU - Tang, Xi
AU - Liang, Minfeng
AU - Quick, Joshua
AU - Song, Tie
AU - Rambaut, Andrew
AU - Loman, Nicholas J.
AU - Raghwani, Jayna
AU - Pybus, Oliver G.
AU - Ke, Changwen
PY - 2020
DA - April
TI - Genomic epidemiology of SARS-CoV-2 in Guangdong Province, China
JO - Cell
EP - 1003.e9
VL - 181
IS - 5
DO - https://doi.org/10.1016/j.cell.2020.04.023
AB - COVID-19 is caused by SARS-CoV-2 infection and was first reported in central China in December 2019. Extensive molecular surveillance in Guangdong, China's most populous province, during early 2020 resulted in 1,388 reported RNA-positive cases from 1.6 million tests. In order to understand the molecular epidemiology and genetic diversity of SARS-CoV-2 in China we generated 53 genomes from infected individuals in Guangdong using a combination of metagenomic sequencing and tiling amplicon approaches. Combined epidemiological and phylogenetic analyses indicate multiple independent introductions to Guangdong, although phylogenetic clustering is uncertain due to low virus genetic variation early in the pandemic. Our results illustrate how the timing, size and duration of putative local transmission chains were constrained by national travel restrictions and by the province's large-scale intensive surveillance and intervention measures. Despite these successes,COVID-19 surveillance in Guangdong is still required as the number of cases imported from other countries has increased.
PB - Elsevier
UR - https://www.research.ed.ac.uk/portal/en/publications/genomic-epidemiology-of-sarscov2-in-guangdong-province-china(f64e3e8b-77a7-4a30-8eb1-bfc863a2571e).html
KW - Coronavirus (COVID-19)
ER