TY - JOUR
AU - Thwaites, Ryan
AU - Uruchurtu, Ashley Sanchez Sevilla
AU - Siggins, Matthew K
AU - Liew, Felicity
AU - Russell, Clark D.
AU - Moore, Shona C.
AU - Fairfield, Cameron J.
AU - Carter, Edwin
AU - Abrams, Simon
AU - Short, Charlotte-Eve
AU - Thaventhiran, Thilipan
AU - Bergstrom, Emma
AU - Gardener, Zoe
AU - Ascough , Stephanie
AU - Chiu, Christopher
AU - Docherty, Annemarie B.
AU - Hunt, David P.J. 
AU - Crow, Janick J.
AU - Solomon, Tom
AU - Taylor , Graham P.
AU - Turtle, Lance C.W.
AU - Harrison, Ewen M.
AU - Dunning, Jake
AU - Semple, Malcolm G.
AU - Baillie, J. Kenneth
AU - Openshaw, Peter J.M.
AU - ISARIC4C Investigators
PY - 2021
DA - March
TI - Inflammatory profiles across the spectrum of disease reveal a distinct role for GM-CSF in severe COVID-19
JO - Science Immunology
VL - 6
IS - 57
DO - https://doi.org/10.1126/sciimmunol.abg9873
AB - While it is now widely accepted that host inflammatory responses contribute to lung injury, the pathways that drive severity and distinguish coronavirus disease 2019 (COVID-19) from other viral lung diseases remain poorly characterized. We analyzed plasma samples from 471 hospitalized patients recruited through the prospective multicenter ISARIC4C study and 39 outpatients with mild disease, enabling extensive characterization of responses across a full spectrum of COVID-19 severity. Progressive elevation of levels of numerous inflammatory cytokines and chemokines (including IL-6, CXCL10, and GM-CSF) were associated with severity and accompanied by elevated markers of endothelial injury and thrombosis. Principal component and network analyses demonstrated central roles for IL-6 and GM-CSF in COVID -19 pathogenesis. Comparing these profiles to archived samples from patients with fatal influenza, IL-6 was equally elevated in both conditions whereas GM-CSF was prominent only in COVID-19. These findings further identify the key inflammatory, thrombotic, and vascular factors that characterize and distinguish severe and fatal COVID-19.
PB - American Association for the Advancement of Science
UR - https://www.research.ed.ac.uk/portal/en/publications/inflammatory-profiles-across-the-spectrum-of-disease-reveal-a-distinct-role-for-gmcsf-in-severe-covid19(9dcd3ceb-fd93-4ed9-aafe-a37c3454c09b).html
KW - Coronavirus (COVID-19)
ER